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Table 4 Factors associated with mortality among 250 patients with HCC (surgically resected between May 2003 and Dec 2011)

From: Prevalence and outcomes of extrahepatic primary malignancy associated with Hepatocellular Carcinoma in a Korean population

Variables Univariate analysis Multivariate analysis
HR 95% CI p value HR 95% CI p-value
Age > 60 years 0.967 0.578–1.616 0.897    
Male sex 0.777 0.394–1.533 0.468    
Diabetes mellitus 1.602 0.880–2.916 0.123    
Hypertension 1.172 0.699–1.965 0.547    
Alcohol drinking 0.676 0.405–1.128 0.134    
Smoking, >10 pack-years 1.069 0.643–1.777 0.796    
Portal vein or major vessel invasion 3.073 1.317–7.172 0.009* 1.066 0.361–3.151 0.908
Microvessel invasion 1.983 1.188–3.310 0.009* 1.850 1.058–3.236 0.031*
Intrahepatic metastasis 1.609 0.923–2.804 0.094    
Alpha-fetoprotein > 20 ng/mL 1.806 1.083–3.014 0.043* 1.716 1.018–2.892 0.043*
Child-Turcotte-Pugh score B or C 0.840 0.361–1.955 0.686    
Presence of EHPM 2.125 1.087–4.155 0.028* 2.002 1.016–3.942 0.045*
pTNM stage > II 2.303 1.285–4.129 0.005* 1.784 0.950–3.351 0.072
  1. CI, confidence interval; EHPM, extrahepatic primary malignant neoplasm; HCC, hepatocellular carcinoma; HR, hazard ratio; pTNM score, pathologic TNM stage.
  2. According to the Cox proportional hazard model.
  3. *p < 0.05.
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