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Table 2 Top ten significantly down-regulated genes in LNCaP cells after EPHB4 siRNA knockdown

From: The tumour-promoting receptor tyrosine kinase, EphB4, regulates expression of Integrin-β8 in prostate cancer cells

Fold change Gene symbol Description Function
-29.4 ITGB8 Integrin beta 8 Cell-cell and cell-extracellular matrix interactions
-10.5 LOC100287846 Patched 1 pseudogene Uncharacterized
-10.5 PROM1 Prominin 1/CD133 Transmembrane glycoprotein, stem cell marker
-10.3 EIF4E3 Eukaryotic translation initiation factor 4E family member 3 Recruits mRNA to ribsosome
-8.8 GBP3 Guanylate Binding Protein 3 Binding of guanidine nucleotides
-8.4 DOCK10 Dedicator of Cytokinesis 10 Guanine nucleotide exchange factor
-7.9 C14orf38 Open reading frame Uncharacterized
-6.9 TMC7 Transmembrane Channel-like 7 Multi-pass membrane protein
-6.8 SASH1 SAM and SH3 domain Containing 1 Candidate tumour suppressor in breast cancer
-5.8 FSD2 Fibronectin type III and SPRY domain containing 2 Uncharacterized