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Table 2 Top ten significantly down-regulated genes in LNCaP cells after EPHB4 siRNA knockdown

From: The tumour-promoting receptor tyrosine kinase, EphB4, regulates expression of Integrin-β8 in prostate cancer cells

Fold change

Gene symbol

Description

Function

-29.4

ITGB8

Integrin beta 8

Cell-cell and cell-extracellular matrix interactions

-10.5

LOC100287846

Patched 1 pseudogene

Uncharacterized

-10.5

PROM1

Prominin 1/CD133

Transmembrane glycoprotein, stem cell marker

-10.3

EIF4E3

Eukaryotic translation initiation factor 4E family member 3

Recruits mRNA to ribsosome

-8.8

GBP3

Guanylate Binding Protein 3

Binding of guanidine nucleotides

-8.4

DOCK10

Dedicator of Cytokinesis 10

Guanine nucleotide exchange factor

-7.9

C14orf38

Open reading frame

Uncharacterized

-6.9

TMC7

Transmembrane Channel-like 7

Multi-pass membrane protein

-6.8

SASH1

SAM and SH3 domain Containing 1

Candidate tumour suppressor in breast cancer

-5.8

FSD2

Fibronectin type III and SPRY domain containing 2

Uncharacterized