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Table 4 Regression analysis between number of SNP risk alleles and log-transformed absolute (top) and relative percent (bottom) fibroglandular tissue volume in Caucasian (left) and African-American (right) women for each of the 12 SNPs evaluated in this study, after adjusting for age, BMI and Gail lifetime risk

From: Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography

Absolute volume density
SNP Caucasian women (N = 389) African-American women (N = 250)
B p-value [95% CI] B p-value [95% CI]
rs1045485 0.011 0.658 −0.039 0.061 −0.005 0.923 −0.097 0.088
rs11249433 0.015 0.399 −0.020 0.051 0.005 0.879 −0.057 0.066
rs1219648 −0.016 0.398 −0.052 0.021 0.004 0.886 −0.046 0.054
rs13281615 0.007 0.706 −0.027 0.041 −0.043 0.071 −0.090 0.004
rs13387042 0.001 0.941 −0.032 0.035 0.003 0.913 −0.047 0.053
rs3803662 0.010 0.599 −0.028 0.048 0.049 0.043 0.002 0.097
rs3817198 −0.045 0.019 −0.082 −0.007 0.008 0.792 −0.051 0.067
rs4415084 0.011 0.567 −0.026 0.047 0.020 0.383 −0.025 0.066
rs4973768 −0.033 0.070 −0.068 0.003 −0.035 0.161 −0.085 0.014
rs6504950 0.008 0.693 −0.032 0.048 0.001 0.964 −0.044 0.047
rs889312 −0.015 0.455 −0.054 0.024 0.027 0.285 −0.023 0.077
rs999737 −0.006 0.797 −0.048 0.037 −0.075 0.176 −0.182 0.033
Volume percent density (VD%)
SNP Caucasian women (N = 389) African-American women (N = 250)
B p-value [95% CI] B p-value [95% CI]
rs1045485 −0.002 0.907 −0.036 0.032 −0.021 0.492 −0.081 0.039
rs11249433 0.017 0.167 −0.007 0.041 −0.021 0.309 −0.061 0.019
rs1219648 −0.016 0.210 −0.041 0.009 −0.017 0.317 −0.049 0.016
rs13281615 −0.014 0.251 −0.037 0.010 0.011 0.490 −0.020 0.041
rs13387042 0.021 0.072 −0.002 0.044 0.008 0.633 −0.025 0.040
rs3803662 0.008 0.522 −0.017 0.034 0.020 0.200 −0.011 0.051
rs3817198 −0.023 0.076 −0.048 0.002 0.023 0.229 −0.015 0.062
rs4415084 0.017 0.179 −0.008 0.041 0.029 0.057 −0.001 0.058
rs4973768 −0.005 0.680 −0.029 0.019 −0.036 0.028 −0.068 −0.004
rs6504950 0.005 0.698 −0.022 0.032 0.011 0.483 −0.019 0.040
rs889312 −0.012 0.386 −0.038 0.015 0.001 0.971 −0.032 0.033
rs999737 0.000 0.984 −0.029 0.028 −0.058 0.109 −0.128 0.013
  1. The regression coefficient estimate for each individual SNP (B), p-values and the 95% confidence interval of the regression coefficients ([95% CI]) are provided. Significant associations are italicized and bolded.