Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography

Keller, Brad M; McCarthy, Anne Marie; Chen, Jinbo; Armstrong, Katrina; Conant, Emily F; Domchek, Susan M; Kontos, Despina

doi:10.1186/s12885-015-1159-3

Table 4 Regression analysis between number of SNP risk alleles and log-transformed absolute (top) and relative percent (bottom) fibroglandular tissue volume in Caucasian (left) and African-American (right) women for each of the 12 SNPs evaluated in this study, after adjusting for age, BMI and Gail lifetime risk

From: Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography

Absolute volume density
SNP	Caucasian women (N = 389)				African-American women (N = 250)
SNP	B	p-value	[95% CI]		B	p-value	[95% CI]
rs1045485	0.011	0.658	−0.039	0.061	−0.005	0.923	−0.097	0.088
rs11249433	0.015	0.399	−0.020	0.051	0.005	0.879	−0.057	0.066
rs1219648	−0.016	0.398	−0.052	0.021	0.004	0.886	−0.046	0.054
rs13281615	0.007	0.706	−0.027	0.041	−0.043	0.071	−0.090	0.004
rs13387042	0.001	0.941	−0.032	0.035	0.003	0.913	−0.047	0.053
*rs3803662*	0.010	0.599	−0.028	0.048	*0.049*	*0.043*	*0.002*	*0.097*
*rs3817198*	*−0.045*	*0.019*	*−0.082*	*−0.007*	0.008	0.792	−0.051	0.067
rs4415084	0.011	0.567	−0.026	0.047	0.020	0.383	−0.025	0.066
rs4973768	−0.033	0.070	−0.068	0.003	−0.035	0.161	−0.085	0.014
rs6504950	0.008	0.693	−0.032	0.048	0.001	0.964	−0.044	0.047
rs889312	−0.015	0.455	−0.054	0.024	0.027	0.285	−0.023	0.077
rs999737	−0.006	0.797	−0.048	0.037	−0.075	0.176	−0.182	0.033
Volume percent density (VD%)
SNP	Caucasian women (N = 389)				African-American women (N = 250)
SNP	B	p-value	[95% CI]		B	p-value	[95% CI]
rs1045485	−0.002	0.907	−0.036	0.032	−0.021	0.492	−0.081	0.039
rs11249433	0.017	0.167	−0.007	0.041	−0.021	0.309	−0.061	0.019
rs1219648	−0.016	0.210	−0.041	0.009	−0.017	0.317	−0.049	0.016
rs13281615	−0.014	0.251	−0.037	0.010	0.011	0.490	−0.020	0.041
rs13387042	0.021	0.072	−0.002	0.044	0.008	0.633	−0.025	0.040
rs3803662	0.008	0.522	−0.017	0.034	0.020	0.200	−0.011	0.051
rs3817198	−0.023	0.076	−0.048	0.002	0.023	0.229	−0.015	0.062
rs4415084	0.017	0.179	−0.008	0.041	0.029	0.057	−0.001	0.058
*rs4973768*	−0.005	0.680	−0.029	0.019	*−0.036*	*0.028*	*−0.068*	*−0.004*
rs6504950	0.005	0.698	−0.022	0.032	0.011	0.483	−0.019	0.040
rs889312	−0.012	0.386	−0.038	0.015	0.001	0.971	−0.032	0.033
rs999737	0.000	0.984	−0.029	0.028	−0.058	0.109	−0.128	0.013

The regression coefficient estimate for each individual SNP (B), p-values and the 95% confidence interval of the regression coefficients ([95% CI]) are provided. Significant associations are italicized and bolded.

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ISSN: 1471-2407

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