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Table 3 Regression analysis between number of SNP risk alleles and log-transformed absolute (top) and relative percent (bottom) area density measures in Caucasian (left) and African-American (right) women for each of the 12 SNPs evaluated in this study, after adjusting for age, BMI and Gail lifetime risk

From: Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography

Absolute area density
SNP Caucasian women (N = 389) African-American women (N = 250)
B p-value [95% CI] B p-value [95% CI]
rs1045485 0.002 0.919 −0.041 0.045 −0.014 0.717 −0.088 0.060
rs11249433 −0.014 0.367 −0.045 0.017 −0.016 0.540 −0.065 0.034
rs1219648 −0.014 0.375 −0.046 0.017 0.021 0.300 −0.019 0.061
rs13281615 0.001 0.970 −0.029 0.030 −0.018 0.363 −0.055 0.020
rs13387042 0.014 0.353 −0.015 0.043 0.008 0.679 −0.031 0.048
rs3803662 0.017 0.309 −0.016 0.050 0.024 0.219 −0.014 0.062
rs3817198 −0.047 0.004 −0.080 −0.015 0.032 0.175 −0.014 0.079
rs4415084 0.021 0.182 −0.010 0.053 −0.003 0.876 −0.039 0.034
rs4973768 −0.005 0.760 −0.035 0.026 −0.035 0.080 −0.074 0.004
rs6504950 0.008 0.650 −0.027 0.043 −0.009 0.633 −0.046 0.028
rs889312 −0.022 0.194 −0.056 0.011 0.003 0.873 −0.037 0.043
rs999737 −0.020 0.280 −0.057 0.016 −0.050 0.262 −0.137 0.037
Area percent density (PD%)
SNP Caucasian women (N = 389) African-American women (N = 250)
B p-value [95% CI] B p-value [95% CI]
rs1045485 −0.002 0.934 −0.049 0.045 −0.022 0.626 −0.112 0.067
rs11249433 −0.007 0.674 −0.040 0.026 −0.027 0.370 −0.087 0.032
rs1219648 −0.011 0.524 −0.045 0.023 0.008 0.760 −0.041 0.056
rs13281615 −0.014 0.382 −0.046 0.018 0.010 0.659 −0.035 0.056
rs13387042 0.025 0.117 −0.006 0.056 0.004 0.878 −0.045 0.052
rs3803662 0.020 0.269 −0.015 0.055 0.004 0.866 −0.042 0.050
rs3817198 −0.033 0.061 −0.068 0.002 0.046 0.108 −0.010 0.103
rs4415084 0.025 0.149 −0.009 0.059 0.006 0.776 −0.038 0.051
rs4973768 0.015 0.388 −0.018 0.048 −0.029 0.239 −0.077 0.019
rs6504950 0.013 0.504 −0.025 0.050 −0.007 0.768 −0.051 0.037
rs889312 −0.017 0.352 −0.053 0.019 −0.012 0.621 −0.061 0.036
rs999737 −0.015 0.461 −0.054 0.025 −0.038 0.480 −0.142 0.067
  1. The regression coefficient estimate for each individual SNP (B), p-values and the 95% confidence interval of the regression coefficients ([95% CI]) are provided. Significant associations are italicized and bolded.