Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography

Keller, Brad M; McCarthy, Anne Marie; Chen, Jinbo; Armstrong, Katrina; Conant, Emily F; Domchek, Susan M; Kontos, Despina

doi:10.1186/s12885-015-1159-3

Table 3 Regression analysis between number of SNP risk alleles and log-transformed absolute (top) and relative percent (bottom) area density measures in Caucasian (left) and African-American (right) women for each of the 12 SNPs evaluated in this study, after adjusting for age, BMI and Gail lifetime risk

From: Associations between breast density and a panel of single nucleotide polymorphisms linked to breast cancer risk: a cohort study with digital mammography

Absolute area density
SNP	Caucasian women (N = 389)				African-American women (N = 250)
SNP	B	p-value	[95% CI]		B	p-value	[95% CI]
rs1045485	0.002	0.919	−0.041	0.045	−0.014	0.717	−0.088	0.060
rs11249433	−0.014	0.367	−0.045	0.017	−0.016	0.540	−0.065	0.034
rs1219648	−0.014	0.375	−0.046	0.017	0.021	0.300	−0.019	0.061
rs13281615	0.001	0.970	−0.029	0.030	−0.018	0.363	−0.055	0.020
rs13387042	0.014	0.353	−0.015	0.043	0.008	0.679	−0.031	0.048
rs3803662	0.017	0.309	−0.016	0.050	0.024	0.219	−0.014	0.062
*rs3817198*	*−0.047*	*0.004*	*−0.080*	*−0.015*	0.032	0.175	−0.014	0.079
rs4415084	0.021	0.182	−0.010	0.053	−0.003	0.876	−0.039	0.034
rs4973768	−0.005	0.760	−0.035	0.026	−0.035	0.080	−0.074	0.004
rs6504950	0.008	0.650	−0.027	0.043	−0.009	0.633	−0.046	0.028
rs889312	−0.022	0.194	−0.056	0.011	0.003	0.873	−0.037	0.043
rs999737	−0.020	0.280	−0.057	0.016	−0.050	0.262	−0.137	0.037
Area percent density (PD%)
SNP	Caucasian women (N = 389)				African-American women (N = 250)
SNP	B	p-value	[95% CI]		B	p-value	[95% CI]
rs1045485	−0.002	0.934	−0.049	0.045	−0.022	0.626	−0.112	0.067
rs11249433	−0.007	0.674	−0.040	0.026	−0.027	0.370	−0.087	0.032
rs1219648	−0.011	0.524	−0.045	0.023	0.008	0.760	−0.041	0.056
rs13281615	−0.014	0.382	−0.046	0.018	0.010	0.659	−0.035	0.056
rs13387042	0.025	0.117	−0.006	0.056	0.004	0.878	−0.045	0.052
rs3803662	0.020	0.269	−0.015	0.055	0.004	0.866	−0.042	0.050
rs3817198	−0.033	0.061	−0.068	0.002	0.046	0.108	−0.010	0.103
rs4415084	0.025	0.149	−0.009	0.059	0.006	0.776	−0.038	0.051
rs4973768	0.015	0.388	−0.018	0.048	−0.029	0.239	−0.077	0.019
rs6504950	0.013	0.504	−0.025	0.050	−0.007	0.768	−0.051	0.037
rs889312	−0.017	0.352	−0.053	0.019	−0.012	0.621	−0.061	0.036
rs999737	−0.015	0.461	−0.054	0.025	−0.038	0.480	−0.142	0.067

The regression coefficient estimate for each individual SNP (B), p-values and the 95% confidence interval of the regression coefficients ([95% CI]) are provided. Significant associations are italicized and bolded.

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ISSN: 1471-2407

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