Figure 6From: Ras induces experimental lung metastasis through up-regulation of RbAp46 to suppress RECK promoter activity A schematic hypothetical model shows that RbAp46 is a Ras up-regulated gene which participates in Ras-induced experimental lung metastasis through binding with HDAC1 and Sp1 to suppress RECK expression followed by MMP-9 activation and metastasis. Back to article page