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Table 2 Median [range] and p-value of percentage change in parameters between imaging timepoints (Baseline, Fraction 11 and Fraction 21)

From: Alterations in anatomic and functional imaging parameters with repeated FDG PET-CT and MRI during radiotherapy for head and neck cancer: a pilot study

Parameter

Baseline to Fraction 11

Baseline to Fraction 21

Fraction 11 to Fraction 21

GTV-CT

−24 [−78,−6]

−53 [−82,−27]

−23 [−53,−13]

(cm3)

p = 0.016

p = 0.016

p = 0.016

GTV-MR

−31 [−88,−3]

−70 [−92,−61]

−58 [−81,−32]

(cm3)

p = 0.008

p = 0.031

p = 0.031

GTV-DW

−53 [−77,−19]

−79 [−93,−63]

−62 [−73,−36]

(cm3)

p = 0.008

p = 0.031

p = 0.031

GTV-PET

−20 [−49,105]

−16 [−69,374]

18 [−64,132]

(cm3)

p = 0.375

p = 0.297

p = 0.578

SUVmax

−26 [−84,−18]

−60 [−78,−33]

−19 [−47,36]

p = 0.016

p = 0.016

p = 0.219

Mean ADC value

37 [6,64]

48 [−1,105]

16 [−37,41]

(x10−3mm2s−1)

p = 0.008

p = 0.063

p = 0.563

Plasma Flow (ml/min/100 ml)

35 [15,205]

62 [35,77]

7 [4,54]

p = 0.008

p = 0.063

p = 0.063

Plasma Volume

36 [18,155]

31 [−32,45]

−2 [−53,8]

(ml/100 ml)

p = 0.008

p = 0.313

p = 0.625

Interstitial Volume

11 [−47,165]

99 [−6,213]

37 [18,129]

(ml/100 ml)

p = 0.461

p = 0.125

p = 0.063

Permeability Surface Area Product (ml/min/100 ml)

12 [−33,240]

290 [1,481]

75 [21,360]

p = 0.313

p = 0.063

p = 0.063

Extraction Fraction (%)

−21 [−62,150]

118 [−32,286]

55 [12,290]

p = 0.641

p = 0.313

p = 0.063

Ktrans (min−1)

16 [−28,222]

15 [−100,422]

41 [−100,307]

p = 0.148

p = 0.461

p = 0.742

  1. Statistically significant results indicated in bold type.