Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer

Table 4 The prognostic associations of KRAS mutation, BRAF mutation and MSI in right versus left colon in 121 patients with colon cancer

	Diseasestage II and III				All
	Recurrence	No recurrence	Odds ratio (95% Confidence interval)	P	Disseminated^¥	Non-disseminated^β	Odds ratio (95% Confidence interval)	P
Rightcolon
MSI	5	12	0,40 (0,12-1,31)	0,158	6	12	0,31 (0,10-0,95)	0.055
MSS	22	21			34	21
Leftcolon
MSI	0	5	*	0,057	1	5	0,11 (0,01-1,04)	0.069
MSS	15	15			27	15
Rightcolon
BRAFmutation	6	14	0,38 (0,12-1,21)	0,168	10	14	0,45 (0,17-1,22)	0.138
BRAFwildtype	21	19			30	19
Leftcolon
BRAFmutation	0	4	*	0,119	0	4		0.025
BRAFwildtype	15	16			28	16	*
Rightcolon
BRAF/MSIpresent	7	16	0,37 (0,12-1,12)	0,110	11	16	0,40 (0,15-1,07)	0.089
BRAF/MSI absent	20	17			29	17
Leftcolon
BRAF/MSIpresent	0	6	*	0,024	1	6	0,09 (0,01-0,79)	0.015
BRAF/MSI absent	15	14			27	14
Rightcolon
KRASmutation	13	10	2,13 (0,74-6,16)	0,157	20	10	2,3 (0,87-6,05)	0.089
KRASwildtype	14	23			20	23
Leftcolon
KRASmutation	5	4	2,00 (0,43-9,27)	0,451	14	4	4,00 (1,07-15,01)	0.041
KRASwildtype	10	16			14	16

^βNon-disseminated: Disease stage II and III without recurrence; ^¥Disseminated: Disease stage II and III with recurrence and stage IV. *Not able to calculate OR because of 0 in one grupp.

ISSN: 1471-2407