BMC Cancer

Table 2 Correlations between KRAS, BRAF and PIK3CA mutations, MSI (n = 121) and DNA copy number (n = 115) in primary tumours from patients with colon cancer

From: Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer

	BRAF				PIK3CA				MSI vs MSS				DNA copy number
	Mut	Wt	p	r	Mut	Wt	p	r	MSI	MSS	p	r	<2.5	≥2.5	Missing	p	r
KRAS
Mutation	0	48	<0.001	-0.414	9	39	0.100	-0.003	2	46	<0.001	-0.338	22	22	3	0.169	-0.146
Wild type	28	45	<0.001	-0.414	13	60	0.100	-0.003	22	51	<0.001	-0.338	46	25	3	0.169	-0.146
BRAF
Mutation					10	18	0.006	-0.213	18	10	<0.001	0.657	23	5		0.009	0.265
Wild type					12	81	0.006	-0.213	6	87	<0.001	0.657	45	42	6	0.009	0.265
PIK3CA
Mutation									8	14	0.041	0.173	14	7	1	0.595	0.072
Wild type									16	83	0.041	0.173	54	40	5	0.595	0.072
MSI
MSI													23	0	1	<0.001	0.416
MSS													45	47	5	<0.001	0.416

Wt: Wild type; Mut: Mutation; r: Correlation coefficient.

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ISSN: 1471-2407

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