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Table 1 Clinical and histopathological relations of KRAS, BRAF and PIK3CA mutations and MSI (n = 121) and DNA copy number (n = 116) in primary tumours of patients with colon cancer

From: Microsatellite instability and mutations in BRAF and KRAS are significant predictors of disseminated disease in colon cancer

 

Total

Kras wt

Kras mut

p

Braf wt

Braf mut

p

PIK3CA wt

PIK3CA mut

p

MSS

MSI

p

DNA copy number

p

<2.5

≥2.5

Number

121

73

48

 

93

28

 

97

22

 

97

24

 

66

50

 

Age at diagnosis

                

 Years (mean)

70

71

69

0,346

69

72

0,388

71

67

0,380

70

70

0,858

71

69

0,412

Gender

                

 Female

71

43

28

0.950

51

20

0.132

57

14

0.641

54

17

0.177

37

31

0.520

 Male

50

30

20

 

42

8

 

42

8

 

43

7

 

29

19

 

Tumour location

                

 Right colon

73

43

30

0.692

49

24

0.002

56

17

0.093

55

18

0.110

39

31

0.751

 Left colon

48

30

18

 

44

4

 

43

5

 

42

6

 

27

19

 

Tumour stage

                

 Stage II

40

29

11

0,008

28

12

0,160

35

5

0,147

27

13

0,010

26

14

0,247

 Stage III

55

34

21

 

43

12

 

45

10

 

46

9

 

28

25

 

 Stage IV

26

10

16

 

22

4

 

19

7

 

24

2

 

12

11

 

Tumour size

                

 <5 cm

38

22

16

0.749

31

7

0.639

31

7

0.100

36

2

0.011

21

16

0.972

 ≥5 cm

82

50

32

 

62

20

 

67

15

 

61

21

 

44

34

 

 Missing data

1

               

Differentiation

                

 Poor

28

20

8

0,193

18

10

0.072

18

10

0.006

14

14

<0.001

18

9

0.274

 Well-moderate

93

53

40

 

75

18

 

81

12

 

83

10

 

48

41

 

Mucinous

                

 No

102

62

40

0,804

81

21

0.143

84

18

0.748

84

18

0.208

55

42

0.100

 Yes

19

11

8

 

12

7

 

15

4

 

13

6

 

11

8

 

Perineural invasion

                

 No

117

71

2

0.649

89

28

0.572

97

20

0.151

93

24

0.583

64

49

1.000

 Yes

4

46

2

 

4

0

 

2

2

 

4

0

 

2

1

 

Vascular invasion

                

 No

104

65

39

0,287

78

26

0.354

85

18

1.000

81

23

0.189

58

42

0.549

 Yes

17

8

9

 

15

2

 

14

3

 

16

1

 

8

8

 
  1. Wt: wildtype; mut: mutation.