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Table 1 Cytotoxic activities of cyproheptadine in HCC cell lines after 24 h of treatment

From: Cyproheptadine, an antihistaminic drug, inhibits proliferation of hepatocellular carcinoma cells by blocking cell cycle progression through the activation of P38 MAP kinase

IC50(µM)a Selectivity index (SIb)
HHc HepG2 Huh-7 HepG2 Huh-7
118.1 ± 6.4 44.4 ± 6.1 44.7 ± 6.1 2.7 2.6
  1. aData are expressed as the means ± SD of ≥4 replicates.
  2. bAn SI value >2.6 indicates a high degree of cytotoxic selectivity.
  3. cNormal human hepatocytes.