Figure 12

Inhibition of FGFR and response in phosphorylation status of PKM2 and LDHA. Inhibiton experiments were performed with Dovitinib and SU-5402, two inhibitors of Fibroblast growth factor receptor (FGFR). Phosphorylation status of PKM2 and LDHA was measured after four hours and showed a significant decrease with Dovitinib 100nM and SU-5402 20 μM for both proteins. DMSO was used as positive control. No significant downregulation of PKM2 and LDHA phosphorylation was detectable with 1nM and 10 nM of Dovitinib.