Cell type- and tumor zone-specific expression of pVEGFR-1 and its ligands influence colon cancer metastasis

BMC Cancer

Table 5 Numerical and percentage distribution of VEGFR-1/pVEGFR-1 co-expression tumor cells

	N0/M0 n (%)	N+ n (%)	N0/M0 vs. N + p	M+ n (%)	N0/M0 vs. M + p
Co-expression in the tumor center
VEGFR-1+/pVEGFR-1^Tyr1048+	36/32 (89)	19/13 (68)	NS 0.08	21/13 (62)	0.02
VEGFR-1+/pVEGFR-1^Tyr1213+	36/28 (78)	19/12 (63)	NS 0.3	21/10 (48)	0.02
VEGFR-1+/pVEGFR-1^Tyr1333+	36/22 (61)	19/9 (47)	NS 0.4	21/10 (48)	NS 0.4
Co-expression in tumor budding regions
VEGFR-1+/pVEGFR-1^Tyr1048 +	26/25 (96)	19/13 (68)	0.02	22/14 (64)	0.005
VEGFR-1+/pVEGFR-1^Tyr1213 +	26/21 (81)	19/9 (47)	0.02	22/11 (50)	0.01
VEGFR-1+/pVEGFR-1^Tyr1333 +	26/13 (50)	19/9 (47)	NS 1.0	22/9 (41)	NS 0.6

n: total number of VEGFR-1 positive cases/total number of pVEGFR-1 positive cases with concomitant VEGFR-1 positivity. p < 0.05 statistically significant, NS not significant.

ISSN: 1471-2407