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Table 2 Numerical distribution of ligand/VEGFR-1 correlations in tumor cells of CC tissue

From: Cell type- and tumor zone-specific expression of pVEGFR-1 and its ligands influence colon cancer metastasis

  VEGFR-1 VEGF p PlGF p VEGF-B p
  + - (r) + - (r) + - (r)
Tumor center
CC + 68 8 0.0001 66 10 0.007 23 56 NS 0.4
  - 3 7 (0.5) 4 5 (0.3) 1 6 (0.1)
N0/M0 + 32 4 0.009 31 5 NS 0.7 6 30 NS 0.7
  - 0 1 (0.4) 1 0 (0.07) 0 1 (0.07)
N+ + 16 3 0.04 17 3 0.009 7 15 NS 0.4
  - 2 3 (0.4) 1 3 (0.5) 0 2 (0.1)
M+ + 20 1 0.0001 18 2 0.04 10 11 NS 0.6
  - 1 3 (0.7) 2 2 (0.4) 1 3 (0.1)
Tumor budding
CC + 59 10 NS 0.4 60 7 0.02 21 47 NS 0.6
  - 2 1 (0.01) 2 3 (0. 4) 1 4 (0.05)
N0/M0 + 24 3 0.01 24 3 NS 0.7 7 20 NS 0.6
  - 0 1 (0.5) 1 0 (0.09) 0 1 (0.1)
N+ + 16 3 NS 0.7 17 2 0.01 4 15 NS 0.6
  - 1 0 (0.1) 0 1 (0.5) 0 1 (0.1)
M+ + 19 4 NS 0.7 19 2 0.01 10 12 NS 0.7
  - 1 0 (0.1) 1 2 (0.5) 1 2 (0.07)
  1. Positive tumoral expression of VEGFR-1 is positively correlated with positive tumoral VEGF expression in the tumor center and positive tumoral PlGF expression in the tumor center and tumor budding regions. r = Spearman’s rank correlation coefficient. p < 0.05 was taken as statistically significant. NS, not significant.