Cell type- and tumor zone-specific expression of pVEGFR-1 and its ligands influence colon cancer metastasis

BMC Cancer

Table 2 Numerical distribution of ligand/VEGFR-1 correlations in tumor cells of CC tissue

	VEGFR-1	VEGF		p	PlGF		p	VEGF-B		p
		+	-	(r)	+	-	(r)	+	-	(r)
Tumor center
CC	+	68	8	0.0001	66	10	0.007	23	56	NS 0.4
	-	3	7	(0.5)	4	5	(0.3)	1	6	(0.1)
N0/M0	+	32	4	0.009	31	5	NS 0.7	6	30	NS 0.7
	-	0	1	(0.4)	1	0	(0.07)	0	1	(0.07)
N+	+	16	3	0.04	17	3	0.009	7	15	NS 0.4
	-	2	3	(0.4)	1	3	(0.5)	0	2	(0.1)
M+	+	20	1	0.0001	18	2	0.04	10	11	NS 0.6
	-	1	3	(0.7)	2	2	(0.4)	1	3	(0.1)
Tumor budding
CC	+	59	10	NS 0.4	60	7	0.02	21	47	NS 0.6
	-	2	1	(0.01)	2	3	(0. 4)	1	4	(0.05)
N0/M0	+	24	3	0.01	24	3	NS 0.7	7	20	NS 0.6
	-	0	1	(0.5)	1	0	(0.09)	0	1	(0.1)
N+	+	16	3	NS 0.7	17	2	0.01	4	15	NS 0.6
	-	1	0	(0.1)	0	1	(0.5)	0	1	(0.1)
M+	+	19	4	NS 0.7	19	2	0.01	10	12	NS 0.7
	-	1	0	(0.1)	1	2	(0.5)	1	2	(0.07)

Positive tumoral expression of VEGFR-1 is positively correlated with positive tumoral VEGF expression in the tumor center and positive tumoral PlGF expression in the tumor center and tumor budding regions. r = Spearman’s rank correlation coefficient. p < 0.05 was taken as statistically significant. NS, not significant.

ISSN: 1471-2407