| | Score | N0/M0 (%) | N+ (%) | N0/M0 vs. N + p | M+ (%) | N0/M0 vs. M + p | CC (%) |
|---|
Tumor center
|
VEGF
| 0 | 14 | 25 | NS 0.3 | 16 | NS 1.0 | 18 |
1 | 68 | 54 | 60 | 82 |
2 | 18 | 21 | 24 | |
PlGF
| 0 | 14 | 21 | NS 0.5 | 16 |
0.04
| 17 |
1 | 48 | 54 | 72 | 83 |
2 | 38 | 25 | 12 | |
VEGF-B
| 0 | 84 | 83 | NS 1.0 | 56 |
0.02
| 74 |
1 | 16 | 17 | 44 | 26 |
2 | 0 | 0 | 0 | |
Tumor budding
|
VEGF
| 0 | 14 | 15 | NS 1.0 | 17 | NS 1.0 | 15 |
1 | 72 | 60 | 58 | 85 |
2 | 14 | 25 | 25 | |
PlGF
| 0 | 11 | 18 | NS 1.0 | 16 |
0.03
| 15 |
1 | 50 | 46 | 72 | 85 |
2 | 39 | 36 | 12 | |
VEGF-B
| 0 | 75 | 80 | NS 1.0 | 56 | NS 0.06 | 70 |
1 | 14 | 15 | 36 | 30 |
2 | 11 | 5 | 8 | |
- The intensity of the tumoral staining was scored on a semiquantitative scale from 0 to 2 for the investigated biomolecule (0: no staining, 1: weak staining, 2: strong staining). For the statistical analysis using Fisher’s exact test the examined cases were separated into two groups characterized by a negative/positive expression for VEGF and VEGF-B or negative, low/high expression for PlGF. The line in the score (staining intensity) column indicates this dichotomization for each biomolecule. The line in the column “CC %” indicates the percentage distribution of colon carcinomas with negative and positive expression of each biomolecule. p < 0.05 was taken as statistically significant. NS, not significant.
