| |
Score
|
N0/M0 (%)
|
N+ (%)
|
N0/M0 vs. N + p
|
M+ (%)
|
N0/M0 vs. M + p
|
CC (%)
|
|---|
|
Tumor center
|
|
VEGF
|
0
|
14
|
25
|
NS 0.3
|
16
|
NS 1.0
|
18
|
|
1
|
68
|
54
|
60
|
82
|
|
2
|
18
|
21
|
24
| |
|
PlGF
|
0
|
14
|
21
|
NS 0.5
|
16
|
0.04
|
17
|
|
1
|
48
|
54
|
72
|
83
|
|
2
|
38
|
25
|
12
| |
|
VEGF-B
|
0
|
84
|
83
|
NS 1.0
|
56
|
0.02
|
74
|
|
1
|
16
|
17
|
44
|
26
|
|
2
|
0
|
0
|
0
| |
|
Tumor budding
|
|
VEGF
|
0
|
14
|
15
|
NS 1.0
|
17
|
NS 1.0
|
15
|
|
1
|
72
|
60
|
58
|
85
|
|
2
|
14
|
25
|
25
| |
|
PlGF
|
0
|
11
|
18
|
NS 1.0
|
16
|
0.03
|
15
|
|
1
|
50
|
46
|
72
|
85
|
|
2
|
39
|
36
|
12
| |
|
VEGF-B
|
0
|
75
|
80
|
NS 1.0
|
56
|
NS 0.06
|
70
|
|
1
|
14
|
15
|
36
|
30
|
|
2
|
11
|
5
|
8
| |
- The intensity of the tumoral staining was scored on a semiquantitative scale from 0 to 2 for the investigated biomolecule (0: no staining, 1: weak staining, 2: strong staining). For the statistical analysis using Fisher’s exact test the examined cases were separated into two groups characterized by a negative/positive expression for VEGF and VEGF-B or negative, low/high expression for PlGF. The line in the score (staining intensity) column indicates this dichotomization for each biomolecule. The line in the column “CC %” indicates the percentage distribution of colon carcinomas with negative and positive expression of each biomolecule. p < 0.05 was taken as statistically significant. NS, not significant.
