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Table 1 Percentage distribution of the VEGFR-1 ligands in tumor cells of CC tissue

From: Cell type- and tumor zone-specific expression of pVEGFR-1 and its ligands influence colon cancer metastasis

  Score N0/M0 (%) N+ (%) N0/M0 vs. N + p M+ (%) N0/M0 vs. M + p CC (%)
Tumor center
VEGF 0 14 25 NS 0.3 16 NS 1.0 18
1 68 54 60 82
2 18 21 24  
PlGF 0 14 21 NS 0.5 16 0.04 17
1 48 54 72 83
2 38 25 12  
VEGF-B 0 84 83 NS 1.0 56 0.02 74
1 16 17 44 26
2 0 0 0  
Tumor budding
VEGF 0 14 15 NS 1.0 17 NS 1.0 15
1 72 60 58 85
2 14 25 25  
PlGF 0 11 18 NS 1.0 16 0.03 15
1 50 46 72 85
2 39 36 12  
VEGF-B 0 75 80 NS 1.0 56 NS 0.06 70
1 14 15 36 30
2 11 5 8  
  1. The intensity of the tumoral staining was scored on a semiquantitative scale from 0 to 2 for the investigated biomolecule (0: no staining, 1: weak staining, 2: strong staining). For the statistical analysis using Fisher’s exact test the examined cases were separated into two groups characterized by a negative/positive expression for VEGF and VEGF-B or negative, low/high expression for PlGF. The line in the score (staining intensity) column indicates this dichotomization for each biomolecule. The line in the column “CC %” indicates the percentage distribution of colon carcinomas with negative and positive expression of each biomolecule. p < 0.05 was taken as statistically significant. NS, not significant.