Figure 5

Signatures of genomic instability in CUPs. Messenger RNA signatures of chromosomal instability (CIN), DNA double-strand break repair, nucleotide excision repair (NER), base excision repair (BER) and mismatch repair (MMR) in CUPs and MOKO were examined with the Broad Institute GSEA v 2 software. The names of the individual signatures, the number of transcripts and the normalized enrichment scores (NES) are indicated. The right panel depicts the transcript ranking on a colometric scale. With the exception of the CIN signature obtained from [10] all gene lists were retrieved from http://www.broadinstitute.org/gsea/msigdb.