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Table 4 Distribution of 6 HR-HPV types’ viral load regarding biopsy results

From: The DNA load of six high-risk human papillomavirus types and its association with cervical lesions

Viral type

Negative (n = 28)

CIN 1 (n = 16)

CIN 2+ (n = 1)

% (n)

Viral load, median (IQR)

% (n)

Viral load, median (IQR)

% (n)

Viral load, median (IQR)

Absolute

Normalised*

Absolute

Normalised*

Absolute

Normalised*

HPV-16

66.67 (22)

6.42 (1.69)

1.79 (0.54)

57.89 (11)

6.77 (3.04)

1.69 (0.64)

0

n/a

n/a

HPV-18

66.67 (22)

6.29 (1.34)

1.84 (0.51)

68.42 (13)

6.61 (2.28)

1.67 (1.79)

100 (1)

7.02 (n/a)

2.07 (n/a)

HPV-31

30.30 (10)

8.51 (1.90)

2.39 (0.38)

31.58 (6)

9.69 (6.00)

3.50 (2.17)

0

n/a

n/a

HPV-33

3.03 (1)

6.75 (n/a)

1.98 (n/a)

10.53 (2)

8.48 (1.70)

2.37 (2.06)

100 (1)

10.57 (n/a)

3.13 (n/a)

HPV-45

51.52 (17)

6.13 (2.95)

1.79 (1.00)

42.11 (8)

6.24 (1.17)

1.61 (0.80)

0

n/a

n/a

HPV-58

21.21 (7)

5.93 (3.89)

2.14 (2.35)

36.84 (7)

6.12 (0.34)

1.75 (0.28)

0

n/a

n/a

HR-HPV**

94.34 (31)

6.37 (1.20)

2.06 (0.63)

94.74 (18)

6.77 (2.97)

2.12 (1.37)

100 (1)

8.80 (n/a)

2.60 (n/a)

  1. Absolute and normalised viral loads were both log10 transformed.
  2. *HPV copies/cell = number of HPV copies/(number of HMBS copies/2).
  3. **HR-HPV: high risk-human papillomavirus, infection by at least one high-risk viral type from the 6 analysed here.
  4. HPV: human papillomavirus; CIN: cervical intraepithelial neoplasia; CIN 1: cervical intraepithelial neoplasia 1; CIN 2+: cervical intraepithelial neoplasia 2 or 3; n/a: not applicable.