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Table 5 Prognostic value of angiogenic factors in the tumor tissue

From: Association of angiogenic factors with prognosis in esophageal cancer

Tissue factor Median   n % Median survival (IQR) 95% CI 3-Y-S (%) p Value
G-CSF 6,1 ≤ Median 30 51,7% 33,7 (17,0;*) 15,7 - 51,8 40,6% 0,181
   > Median 28 48,3% 14,0 (10,5;*) 2,5 - 25,6 32,1%  
PECAM-1 31356,1 < Median 29 50,0% 29,1 (12,3;*) - 47,9% 0,251
   > Median 29 50,0% 22,6 (11,9;*) 13,9 - 31,3 28,7%  
HGF 5417,1 < Median 29 50,0% n.r. - 51,3% 0,037
   > Median 29 50,0% 20,3 (10,9;36,7) 11,7 - 28,8 24,2%  
VEGF 42,5 < Median 29 50,0% 23,8 (17,0;*) 12,9 - 34,8 36,6% 0,475
   > Median 29 50,0% 22,6 (10,5;*) 0,0 - 47,7 36,9%  
Leptin 109,5 < Median 29 50,0% 22,6 (14,0;*) 4,0 - 41,3 40,6% 0,420
   > Median 29 50,0% 21,7 (10,9;*) 4,8 - 38,7 33,1%  
PDGF-BB 32,5 < Median 29 50,0% 28,5 (14,0;*) 19,0 - 38,0 32,3% 0,777
   > Median 29 50,0% 21,7 (10,9;*) 10,4 - 32,9 40,3%  
Angiopoietin-2 371,5 < Median 29 50,0% 22,6 (11,9;*) 1,3 - 44,0 40,3% 0,712
   > Median 29 50,0% 23,8 (12,3;*) 9,7 - 37,9 34,5%  
Follistatin 557,7 < Median 29 50,0% 36,7 (19,1;*) - 47,9% 0,036
   > Median 29 50,0% 16,0 (10,9;*) 10,6 - 21,4 26,2%  
IL-8 59,7 ≤ Median 30 51,7% 21,7 (13,8;*) 2,8 - 40,7 41,0% 0,431
   > Median 28 48,3% 22,6 (10,5;*) 12,1 - 33,1 32,5%  
Ang-2/VEGF-Ratio 5,7 < Median 29 50,0% 33,7 (11,9;*) - 46,0% 0,594
   > Median 29 50,0% 21,7 (13,8;*) 11,7 - 31,8 30,0%  
  1. Median survival shown in months; n.r.: not reached; CI: confidence interval; 3-Y-S: 3-Year-Survival; IQR: inter quartile range (1st quartile; 3rd quartile (* 3rd quartile not reached)); statistically significant factors are marked in bold.