Variables | Unadjusted HR | 95% CI | P-values | Adjusted HR | 95% CI | p-values |
---|---|---|---|---|---|---|
Patient characteristics | ||||||
Age (per SD increase) | 1.05 | 0.86 – 1.28 | 0.64 | 1.02 | 0.84 – 1.25 | 0.83 |
Diastolic blood pressure (per 10 mmHg increase) | 1.10 | 0.90 – 1.34 | 0.35 | - | - | - |
Systolic blood pressures (per 10 mmHg increase) | 0.97 | 0.87 – 1.09 | 0.60 | - | - | - |
Previous and current smoker | 1.45 | 0.97 – 2.17 | 0.07 | 1.80 | 1.17 – 2.77 | 0.008 |
Body mass index (per SD increase) | 0.99 | 0.81 – 1.21 | 0.93 | - | - | - |
Daily alcohol use (per gram increase) | 1.09 | 0.85 – 1.41 | 0.49 | - | - | - |
Co-morbidities | ||||||
Diabetes | 1.32 | 0.61 – 2.86 | 0.48 | - | - | - |
Chronic kidney disease | 2.37 | 1.27 – 4.50 | 0.007 | 2.43 | 1.28 – 4.62 | 0.007 |
Cardiovascular disease | 1.30 | 0.74 – 2.27 | 0.36 | - | - | - |
Season at recruitment | ||||||
Spring | Ref | - | 0.39 | Ref | - | - |
Summer | 2.07 | 0.63 – 6.78 | 1.02 | 0.24 – 4.34 | 0.97 | |
Autumn | 1.48 | 0.87 – 2.54 | 1.71 | 0.99 – 3.00 | 0.06 | |
Winter | 1.17 | 0.70 – 1.96 | 1.27 | 0.75 – 2.14 | 0.37 | |
Treatment allocation | ||||||
Calcium supplements | 1.11 | 0.76 – 1.63 | 0.59 | 1.09 | 0.73 – 1.62 | 0.67 |
Laboratory measurements | ||||||
25 (OH) Vit D (nmol/L) | ||||||
>83 | Ref | - | 0.06 | Ref | - | 0.04 |
>64 - 83 | 1.95 | 1.02 – 3.74 | 2.23 | 1.09 – 4.58 | ||
>46 - 64 | 2.27 | 1.21 – 4.27 | 2.55 | 1.24 – 5.26 | ||
0 - 46 | 2.12 | 1.11 – 4.05 | 2.63 | 1.26 – 5.45 | ||
Albumin (per SD increase) | 0.95 | 0.79 – 1.13 | 0.53 | - | - | - |
Calcium (per SD increase) | 1.01 | 0.83 – 1.22 | 0.93 | - | - | - |
Phosphate (per SD increase) | 0.70 | 0.14 – 3.46 | 0.66 | - | - | - |
Estimated GFR (per SD increase) | 1.03 | 0.84 – 1.27 | 0.78 | - | - | - |