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Table 4 Univariate analysis of loco-regional control

From: Nuclear expression of p65 (RelA) in patients receiving post-operative radiotherapy for locally advanced squamous cell carcinoma of the head and neck

  At 1 year (%) At 2 years (%) At 3 years (%) P
P65 expression
Negative 88 76 72  
Positive 43 n.a. n.a. <0.001
Age
  ≤ 60 years 83 70 67  
  ≥ 61 years 90 79 75 0.23
Gender
Female 91 78 78  
Male 84 71 67 0.31
Karnofsky performance score
  ≤ 70 83 69 64  
  ≥ 80 88 77 74 0.19
Hemoglobin level pre-RT
  < 12 g/dl 79 60 60  
  ≥ 12 g/dl 89 78 73 0.037
Tumor Site
Oropharynx 91 83 79  
Oral Cavity/Floor of mouth 74 46 46  
Hypopharynx 82 71 71  
Larynx 87 77 69 0.050
Histologic grade
G1-2 91 78 74  
G3 82 70 67 0.24
HPV status
Negative 84 69 65  
Positive 94 94 94 0.041
T-classification
T1-T2 92 83 77  
T3-T4 80 64 64 0.007
N-classification
N0-N2a 90 82 82  
N2b-N3 83 68 63 0.040
AJCC stage
Stage III 91 82 82  
Stage IV 83 68 63 0.042
Extent of resection
Complete 88 75 71  
Incomplete 78 67 67 0.46
Chemotherapy
No 87 77 70  
Yes 85 69 69 0.99
  1. n.a. = not available; significant p-values are given in bold.