Nuclear expression of p65 (RelA) in patients receiving post-operative radiotherapy for locally advanced squamous cell carcinoma of the head and neck

Table 3 Univariate analysis of metastases-free survival

	At 1 year (%)	At 2 years (%)	At 3 years (%)	P
P65 expression
Negative	87	79	76
Positive	86	n.a.	n.a.	0.29
Age
≤ 60 years	89	77	74
≥ 61 years	85	82	76	0.90
Gender
Female	91	84	77
Male	86	77	75	0.41
Karnofsky performance score
≤ 70	82	72	63
≥ 80	91	83	81	0.049
Hemoglobin level pre-RT
< 12 g/dl	83	75	75
≥ 12 g/dl	89	80	75	0.79
Tumor Site
Oropharynx	93	87	81
Oral Cavity/Floor of mouth	82	70	70
Hypopharynx	72	55	55
Larynx	91	87	79	0.036
Histologic grade
G1-2	86	78	73
G3	88	79	76	0.90
HPV status
Negative	87	76	72
Positive	95	95	95	0.09
T-classification
T1-T2	95	88	85
T3-T4	80	71	65	0.013
N-classification
N0-N2a	96	90	90
N2b-N3	82	72	67	0.004
AJCC stage
Stage III	95	89	89
Stage IV	83	73	68	0.011
Extent of resection
Complete	90	84	80
Incomplete	74	57	57	0.002
Chemotherapy
No	88	86	82
Yes	86	71	68	0.16

ISSN: 1471-2407