| | |
NAT2 rapid acetylators
|
NAT2 slow/intermediate acetylators
|
---|
Population
|
Risk factors
|
Variables
|
Controls
|
Cases
|
OR (95% CI)a
|
P-value
|
Controls
|
Cases
|
OR (95% CI)a
|
P-value
|
---|
Black
| | | | | | | | | | |
|
Tobacco smoking
|
Never smokers
|
49
|
39
|
1 (Ref)
| |
206
|
132
|
1 (Ref)
| |
| |
Smokersb
|
38
|
51
|
2.58 (0.80-8.25)
|
0.111
|
180
|
220
|
2.76 (1.69-4.52)
|
<0.0001
|
|
Tot cigarettes/day
|
0
|
49
|
39
|
1 (Ref)
| |
206
|
132
|
1 (Ref)
| |
| |
≤9
|
23
|
31
|
2.23 (0.67-7.36)
|
0.189
|
112
|
143
|
3.27 (1.93-5.54)
|
<0.0001
|
| |
≥10
|
13
|
19
|
3.79 (0.92-15.7)
|
0.066
|
58
|
72
|
2.49 (1.34-4.62)
|
0.004
|
|
Alcohol drinking
|
Non-drinkers
|
34
|
39
|
1 (Ref)
| |
164
|
127
|
1 (Ref)
| |
| |
Drinkersc
|
53
|
51
|
0.94 (0.34-2.62)
|
0.903
|
221
|
224
|
0.91 (0.59-1.41)
|
0.675
|
|
Red meat intaked
|
3 times/week or less
|
−
|
55
| | |
−
|
198
|
1 (Ref)
| |
| |
Daily or almost daily
|
−
|
5
| | |
−
|
31
|
1.67 (0.61-4.58)
|
0.316
|
|
White meat intaked
|
3 times/week or less
|
−
|
33
| | |
−
|
113
|
1 (Ref)
| |
| |
Daily or almost daily
|
−
|
27
| | |
−
|
117
|
1.28 (0.72-2.29)
|
0.397
|
Mixed Ancestry
| | | | | | | | | |
|
Tobacco smoking
|
Never smokers
|
8
|
2
|
1 (Ref)
| |
54
|
12
|
1 (Ref)
| |
| |
Smokersb
|
41
|
53
|
−
|
−
|
185
|
191
|
−
|
−
|
|
Tot cigarettes/day
|
0
|
8
|
2
|
1 (Ref)
| |
54
|
12
|
1 (Ref)
| |
| |
≤9
|
22
|
25
|
−
|
−
|
96
|
58
|
−
|
−
|
| |
≥10
|
16
|
27
|
−
|
−
|
74
|
129
|
−
|
−
|
|
Alcohol drinking
|
Non-drinkers
|
15
|
9
|
1 (Ref)
| |
100
|
41
|
1 (Ref)
| |
| |
Drinkersc
|
34
|
47
|
2.43 (0.65-9.15)
|
0.188
|
138
|
162
|
2.77 (1.38-5.58)
|
0.004
|
|
Red meat intaked
|
3 times/week or less
|
−
|
31
| | |
−
|
75
|
1 (Ref)
| |
| |
Daily or almost daily
|
−
|
5
| | |
−
|
43
|
3.55 (1.29-9.82)
|
0.019
|
|
White meat intaked
|
3 times/week or less
|
−
|
20
| | |
−
|
51
|
1 (Ref)
| |
| |
Daily or almost daily
|
−
|
16
| | |
−
|
66
|
1.80 (0.81-4.02)
|
0.149
|
- Samples with unknown acetylator status are not shown.
- Ref = reference allele.
- aOR was adjusted for age, gender, smoking and alcohol consumption status; OR was not calculated for subgroups with low sample size.
- bSmokers = current and former smokers.
- cDrinkers = light to heavy alcohol drinkers.
- dCase-only analysis has been performed for red meat intake due to lack of data from control individuals.