Is stereotactic radiosurgery a rational treatment option for brain metastases from small cell lung cancer? A retrospective analysis of 70 consecutive patients

Table 3 Analysis of factors predicting patient survival after SRS (Proportional hazards model)

Covariate	OS		NS
	P value	Hazard ratio (95% CI)	P value	Hazard ratio (95% CI)
Young (≤65 years)	0.838	1.06 (0.612–1.83)	0.290	0.490 (0.131–1.83)
High KPS (≥90)	0.015	0.493 (0.279–0.871)	0.055	0.236 (0.054–1.03)
Controlled extra-CNS disease	0.365	0.709 (0.337–1.49)	0.150	2.44 (0.715–8.33)
Prior WBRT	0.629	0.868 (0.487–1.54)	0.071	3.81 (0.891–16.3)
Post-SRS chemotherapy	0.077	0.564 (0.299–1.06)	0.350	2.39 (0.383–14.9)
Single BM	0.017	0.419 (0.205–0.857)	0.340	1.69 (0.572–5.00)

SRS stereotactic radiosurgery, OS overall survival, NS neurological death-free survival, CI confidence interval, KPS Karnofsky performance status, WBRT whole brain radiotherapy, BM brain metastases.

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