Skip to main content

Table 2 Comparison of top 3 signatures by hazard ratio model

From: Evaluation of public cancer datasets and signatures identifies TP53 mutant signatures with robust prognostic and predictive value

   BR1042 BR1095 BR1128 BR1141 BRGSE7390
Signatures Clinical RFS DFS DFS RFS RFS
BRmet50 c-index 0.657 0.605 0.637 0.607 0.633
  P value 0.002 <0.001 <0.001 <0.001 0.001
Log-rank test P value 0.002 <0.001 <0.001 <0.001 0.001
Univariate HR 2.8(1.4-5.5) 2.2(1.4-3.3) 2.8(1.5-4.9) 2.2(1.5-3.3) 2.3(1.4-3.8)
  P value 0.002 <0.001 <0.001 <0.001 0.001
Multivariate HR 3.2(1.4-7.5) 1.8(1.1-2.9) 2.0(1.0-3.9) 2.3(1.4-3.6) 3.0(1.6-5.9)
  P value 0.006 0.021 0.035 0.001 0.001
PMID c-index 0.616 0.622 0.665 0.636 0.608
18271932
Sig33
  P value 0.030 <0.001 <0.001 <0.001 0.010
Log-rank test P value 0.030 <0.001 <0.001 <0.001 0.010
Univariate HR 2.0(1.1-3.8) 2.5(1.6 -3.9) 3.5(2.0-6.4) 2.4(1.6-3.6) 1.9(1.2-3.3)
  P value 0.030 <0.001 <0.001 <0.001 0.010
Multivariate HR 1.9(0.8-4.5) 2.0(1.2-3.3) 2.9(1.5-5.6) 2.3(1.5-3.7) 2.7(1.4-5.3)
  P value 0.171 0.006 0.002 <0.001 0.004
PMID c-index 0.517 0.586 0.638 0.549 0.634
16505416
Sig822
  P value 0.698 0.002 <0.001 0.156 0.001
Log-rank test P value 0.698 0.002 <0.001 0.156 0.001
Univariate HR 1.1( 0.4 -1.7) 1.9(1.3-3.0) 2.8(1.6-4.8) 1.4(0.9-2.1) 2.3(1.4-3.9)
  P value 0.698 0.002 0.000 0.155 0.001
Multivariate HR 1.3(0.6-2.7) 1.5(0.9-2.7) 2.3(1.2-4.4) 1.5(1.0-2.4) 2.8(1.4-5.4)
  P value 0.544 0.138 0.014 0.053 0.003
  1. Multivariate HR adjusted by age, grade, continuous tumor size, LN, ER, NPI1.