Table 2 Comparison of top 3 signatures by hazard ratio model

BRmet50

c-index

0.657

0.605

0.637

0.607

0.633

P value

0.002

<0.001

<0.001

<0.001

0.001

Log-rank test

P value

0.002

<0.001

<0.001

<0.001

0.001

Univariate

HR

2.8(1.4-5.5)

2.2(1.4-3.3)

2.8(1.5-4.9)

2.2(1.5-3.3)

2.3(1.4-3.8)

P value

0.002

<0.001

<0.001

<0.001

0.001

Multivariate

HR

3.2(1.4-7.5)

1.8(1.1-2.9)

2.0(1.0-3.9)

2.3(1.4-3.6)

3.0(1.6-5.9)

P value

0.006

0.021

0.035

0.001

0.001

PMID

c-index

0.616

0.622

0.665

0.636

0.608

18271932

Sig33

P value

0.030

<0.001

<0.001

<0.001

0.010

Log-rank test

P value

0.030

<0.001

<0.001

<0.001

0.010

Univariate

HR

2.0(1.1-3.8)

2.5(1.6 -3.9)

3.5(2.0-6.4)

2.4(1.6-3.6)

1.9(1.2-3.3)

P value

0.030

<0.001

<0.001

<0.001

0.010

Multivariate

HR

1.9(0.8-4.5)

2.0(1.2-3.3)

2.9(1.5-5.6)

2.3(1.5-3.7)

2.7(1.4-5.3)

P value

0.171

0.006

0.002

<0.001

0.004

PMID

c-index

0.517

0.586

0.638

0.549

0.634

16505416

Sig822

P value

0.698

0.002

<0.001

0.156

0.001

Log-rank test

P value

0.698

0.002

<0.001

0.156

0.001

Univariate

HR

1.1( 0.4 -1.7)

1.9(1.3-3.0)

2.8(1.6-4.8)

1.4(0.9-2.1)

2.3(1.4-3.9)

P value

0.698

0.002

0.000

0.155

0.001

Multivariate

HR

1.3(0.6-2.7)

1.5(0.9-2.7)

2.3(1.2-4.4)

1.5(1.0-2.4)

2.8(1.4-5.4)

P value

0.544

0.138

0.014

0.053

0.003