Kaplan-Meier estimates of distant relapse–free survival analyses of two predictors of taxane-anthracycline sensitivity. 508 patients with HER2- breast cancer from two independent datasets (GSE25055 and GSE25065) were stratified into two groups according to the taxane-anthracycline centroid correlation. In each survival plot, two types of distant relapse-free survival were prospectively determined before taxane-anthracycline treatment: drug-sensitive (solid red line) and drug-insensitive (dashed black line). The distant relapse-free time in years is displayed on the x-axis, and the y-axis shows the probability of distant relapse-free survival. The P values indicate the statistical significance of survival time differences between the two groups.