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Table 11 Genes chosen most commonly by studies in review

From: Prediction of resistance to chemotherapy in ovarian cancer: a systematic review

Gene symbol Number of studies Function Expression links to cancer in literature
AGR2 4 Cell migration and growth Prostate, breast, ovarian, pancreatic
MUTYH 3 Oxidative DNA damage repair Colorectal
AKAP12 3 Subcellular compartmentation of PKA Colorectal, lung, prostate
TP53 3 Cell cycle regulation Breast
TOP2A 3 Required for DNA replication Breast, prostate, ovarian
FOXA2 3 Liver-specific transcription factor Lung, prostate
SRC 2 Regulation of cell growth Colon, liver, lung, breast, pancreatic
SIVA1 2 Pro-apoptotic protein Many cancers
ALDH9A1 2 Aldehyde dehydrogenase Many cancers
LGR5 2 Associated with stem cells Cancer stem cells
EHF 2 Epithelial differentiation and proliferation Prostate
BAX 2 Apoptotic activator Colon, breast, prostate, gastric, leukaemia
CES2 2 Intestine drug clearance Colorectal
CPE 2 Synthesis of hormones and neurotransmitters  
FGFBP1 2 Cell proliferation, differentiation and migration Colorectal, pancreatic
TUBB4A 2 Component of microtubules  
ZNF12 2 Transcription regulation  
RBM39 2 Steroid hormone receptor-mediated transcription  
RFC3 2 Required for DNA replication  
GNPDA1 2 Triggers calcium oscillations in mammalian eggs  
ANXA3 2 Regulation of cellular growth Prostate, ovarian
NFIB 2 Activates transcription and replication Breast
ACTR3B 2 Actin cyctoskeleton organisation Lung
YWHAE 2 Mediates signal transduction Lung, endometrial
CYP51A1 2 Drug metabolism and lipid synthesis  
HMGCS1 2 Cholesterol synthesis and ketogenesis  
ZMYND11 2 Transcriptional repressor  
FADS2 2 Regulates unsaturation of fatty acids  
SNX7 2 Family involved in intracellular trafficking  
ARHGDIA 2 Regulates the GDP/GTP exchange reaction of the Rho proteins Prostate, lung,
NDST1 2 Inflammatory response Prostate, breast
AOC1 2 Catalyses degredation of such as histamine and spermidine  
DAP 2 Positive mediator of programmed cell death  
ERCC8 2 Transcription-coupled nucleotide excision repair  
GUCY1B3 2 Catalyzes conversion of GTP to the second messenger cGMP  
HDAC1 2 Control of cell proliferation and differentiation Prostate, breast, colorectal, gastric
HDAC2 2 Transcriptional regulation and cell cycle progression Cervical, gastric, colorectal
IGFBP5 2 Cell proliferation, differentiation, survival, and motility Breast
IL6 2 Transcriptional inflammatory response, B cell maturation Many cancers
LSAMP 2 Neuronal surface glycoprotein Osteosarcoma
MDK 2 Cell growth, migration, angiogenesis Many cancers
MYCBP 2 Stimulates the activation of E box-dependent transcription  
S100A10 2 Transport of neurotransmitters Colorectal, lung, breast
SLC1A3 2 Glutamate transporter  
NCOA1 2 Stimulates hormone-dependent transcription Breast, prostate
TIAM1 2 Modulates the activity of Rho GTP-binding proteins Many cancers
VEGFA 2 Angiogenesis, cell growth, cell migration, apoptosis Many cancers
RPL36 2 Component of ribosomal 60S subunit  
LBR 2 Anchors lamina and heterochromatin to the nuclear membrane  
ABCB1 2 ATP-dependent drug efflux pump for xenobiotic compounds Many cancers
FASLG 2 Required for triggering apoptosis in some cell types Many cancers
TIMP1 2 Extracellular matrix, proliferation, apoptosis Many cancers
FN1 2 Cell adhesion, motility, migration processes Many cancers
TGFB1 2 Proliferation, differentiation, adhesion, migration Prostate, breast, colon, lung, bladder
XPA 2 DNA excision repair Many cancers
ABCB10 2 Mitochondrial ATP-binding cassette transporter  
POLH 2 Polymerase capable of replicating UV-damaged DNA for repair  
ITGAE 2 Adhesion, intestinal intraepithelial lymphocyte activation  
ZNF200 2 Zinc finger protein  
COL3A1 2 Collagen type III, occurring in most soft connective tissues  
ACKR3 2 G-protein coupled receptor  
EPHB3 2 Mediates developmental processes Lung, colorectal
NBN 2 Double-strand DNA repair, cell cycle control  
PCF11 2 May be involved in Pol II release following polymerisation  
DFNB31 2 Sterocilia elongation, actin cystoskeletal assembly  
BRCA2 2 Double-strand DNA repair Breast, ovarian
AADAC 2 Arylacetamide deacetylase  
CD38 2 Glucose-induced insulin secretion Leukaemia
CHIT1 2 Involved in degradation of chitin-containing pathogens  
CXCR4 2 Receptor specific for stromal-derived-factor-1 Breast, glioma, kidney, prostate
EFNB2 2 Mediates developmental processes  
MECOM 2 Apoptosis, development, cell differentiation, proliferation Leukaemia
FILIP1 2 Controls neocortical cell migration Ovarian
HSPB7 2 Heat shock protein  
LRIG1 2 Regulator of signaling by receptor tyrosine kinases Glioma
MMP1 2 Breakdown of extracellular matrix Gastric, breast
PSAT1 2 Phosphoserine aminotransferase  
SDF2L1 2 Part of endoplasmic reticulum chaperone complex  
TCF15 2 Regulation of patterning of the mesoderm  
EPHB2 2 Contact-dependent bidirectional signaling between cells Colorectal
ETS1 2 Involved in stem cell development, cell senescence and death Many cancers
TRIM27 2 Male germ cell differentiation Ovarian, endometrial, prostate
MARK4 2 Mitosis, cell cycle control Glioma
B4GALT5 2 Biosynthesis of glycoconjugates and saccharides  
  1. Genes listed by number of papers selecting each gene. Gene function and links to cancer obtained via cursory literature search.