Table 2 Univariate survival analysis of comorbidities, medications and their interactions with surgery

Hypertension

620(52.8)

0.92(0.76-1.11)

0.38

0.92(0.73-1.16)

0.47

0.91(0.66-1.26)

0.57

Interaction with surgery

1.18(0.88-1.60)

0.27

1.00(0.69-1.45)

1.00

1.67(0.99-2.81)

0.05

CAD

184(15.7)

1.00(0.80-1.25)

0.99

0.88(0.66-1.16)

0.36

1.26(0.86-1.84)

0.24

Interaction with surgery

1.05(0.67-1.66)

0.83

0.94(0.51-1.70)

0.83

1.29(0.63-2.64)

0.49

AF

63(5.4)

1.23(0.89-1.71)

0.22

0.84(0.53-1.34)

0.48

2.19(1.36-3.51)

<0.01

Interaction with surgery

0.63(0.28-1.44)

0.28

0.57(0.17-1.95)

0.37

0.68(0.22-2.05)

0.49

COPD

65(5.5)

1.14(0.80-1.62)

0.47

0.69(0.40-1.18)

0.17

2.22(1.37-3.59)

<0.01

Interaction with surgery

0.66(0.29-1.52)

0.33

0.66(0.19-2.31)

0.51

0.68(0.22-2.08)

0.50

Asthma

36(3.1)

1.09(0.68-1.75)

0.71

0.79(0.41-1.53)

0.48

1.81(0.92-3.56)

0.09

Interaction with surgery

1.38(0.59-3.22)

0.46

1.80(0.59-5.46)

0.30

0.93(0.25-3.56)

0.92

Diabetes

193(16.4)

1.10(0.87-1.40)

0.43

1.13(0.85-1.51)

0.39

1.04(0.68-1.61)

0.84

Interaction with surgery

0.98(0.64-1.50)

0.92

0.72(0.42-1.26)

0.25

1.59(0.81-3.15)

0.18

Hypothyroidism/levothyroxine

102(8.7)

0.59(0.42-0.83)

<0.01

0.52(0.33-0.80)

<0.01

0.74(0.43-1.29)

0.29

Interaction with surgery

2.26(1.32-3.86)

<0.01

2.27(1.14-4.52)

0.02

2.21(0.94-5.21)

0.07

ACEi/ARB

350(29.8)

0.99(0.81-1.21)

0.95

0.94(0.73-1.20)

0.60

1.10(0.78-1.56)

0.58

Interaction with surgery

1.06(0.76-1.47)

0.72

0.97(0.64-1.46)

0.87

1.28(0.74-2.22)

0.38

beta-Blocker

217(18.5)

0.95(0.76-1.18)

0.65

1.05(0.81-1.36)

0.73

0.74(0.49-1.12)

0.16

Interaction with surgery

1.07(0.71-1.61)

0.73

0.71(0.42-1.21)

0.21

2.29(1.18-4.43)

0.01

Calcium antagonist

172(14.7)

1.01(0.79-1.30)

0.92

1.05(0.78-1.42)

0.73

0.94(0.60-1.48)

0.79

Interaction with surgery

1.24(0.82-1.86)

0.31

1.06(0.63-1.77)

0.82

1.63(0.82-3.23)

0.16

alpha-1-Adrenoceptor blocker

105(8.9)

1.19(0.90-1.58)

0.23

1.08(0.76-1.55)

0.67

1.45(0.90-2.32)

0.12

Interaction with surgery

1.12(0.67-1.87)

0.66

1.05(0.54-2.04)

0.89

1.20(0.54-2.70)

0.65

Diuretic

200(17.0)

1.01(0.80-1.26)

0.96

0.93(0.7-1.24)

0.63

1.13(0.77-1.66)

0.53

Interaction with surgery

1.18(0.79-1.77)

0.42

1.27(0.77-2.08)

0.35

1.07(0.53-2.16)

0.85

Cardiac glycoside

48(4.1)

1.04(0.72-1.51)

0.83

0.67(0.38-1.17)

0.16

1.83(1.11-3.04)

0.02

Interaction with surgery

2.09(0.94-4.62)

0.07

2.41(0.77-7.51)

0.13

1.82(0.59-5.60)

0.30

Coronary vasodilator

33(2.8)

0.61(0.36-1.04)

0.07

0.67(0.35-1.25)

0.21

0.50(0.19-1.36)

0.18

Interaction with surgery

1.66(0.66-4.15)

0.28

0.69(0.15-3.18)

0.63

3.89(1.02-14.88)

0.05

Bronchodilator

33(2.8)

1.34(0.84-2.15)

0.22

0.53(0.22-1.27)

0.15

3.35(1.89-5.93)

<0.01

Interaction with surgery

0.73(0.27-1.98)

0.53

2.05(0.54-7.74)

0.29

0.21(0.03-1.62)

0.13

Insulin

37(3.2)

0.81(0.47-1.37)

0.43

0.66(0.32-1.32)

0.24

1.17(0.52-2.65)

0.71

Interaction with surgery

1.87(0.67-5.25)

0.23

1.27(0.27-6.07)

0.76

2.76(0.67-11.31)

0.16

Sulfonylurea

75(6.4)

1.34(0.95-1.88)

0.09

1.53(1.04-2.26)

0.03

0.94(0.46-1.93)

0.87

Interaction with surgery

0.71(0.37-1.37)

0.31

0.35(0.13-0.92)

0.03

2.02(0.73-5.59)

0.18

Biguanide

104(8.9)

0.99(0.70-1.40)

0.97

1.11(0.75-1.65)

0.60

0.74(0.36-1.51)

0.41

Interaction with surgery

0.85(0.48-1.49)

0.57

0.62(0.31-1.26)

0.19

1.62(0.60-4.35)

0.34

Antacid

657(56.0)

0.74(0.62-0.89)

<0.01

0.79(0.63-0.99)

0.04

0.67(0.48-0.92)

0.01

Interaction with surgery

1.25(0.92-1.69)

0.15

1.21(0.84-1.76)

0.31

1.30(0.77-2.19)

0.30

NSAIDs

507(43.2)

1.10(0.92-1.33)

0.30

1.06(0.84-1.33)

0.63

1.19(0.86-1.64)

0.30

Interaction with surgery

0.90(0.66-1.22)

0.50

0.89(0.61-1.29)

0.54

0.94(0.55-1.6)

0.82

Statins

400(34.1)

0.84(0.69-1.02)

0.08

0.81(0.64-1.04)

0.09

0.87(0.62-1.23)

0.43

Interaction with surgery

1.19(0.86-1.64)

0.30

1.05(0.70-1.56)

0.81

1.53(0.89-2.66)

0.13

Variables

NO. (%)

HR(95%CI) ¹

P ¹

HR(95%CI) ¹

P ¹

HR(95%CI) ¹

P ¹

Other lipid-regulating agents

60(5.1)

0.88(0.55-1.41)

0.60

1.08(0.64-1.82)

0.77

0.46(0.15-1.45)

0.19

Interaction with surgery

0.75(0.36-1.56)

0.45

0.41(0.16-1.07)

0.07

2.53(0.64-10.06)

0.19

Antithrombotic

119(10.1)

0.99(0.75-1.30)

0.94

0.86(0.61-1.22)

0.40

1.29(0.83-2.00)

0.25

Interaction with surgery

1.03(0.59-1.80)

0.93

0.91(0.43-1.93)

0.80

1.19(0.51-2.78)

0.68

Antidepressant

215(18.3)

0.99(0.79-1.24)

0.92

0.98(0.74-1.30)

0.91

1.01(0.67-1.50)

0.97

Interaction with surgery

1.06(0.72-1.57)

0.76

0.89(0.55-1.47)

0.66

1.43(0.75-2.73)

0.27