Systematic review of the predictive effect of MSI status in colorectal cancer patients undergoing 5FU-based chemotherapy

Table 2 Study characteristics

		Study sample characteristics				5FU Treatment regimen	MSI assessment			Included in HR meta-analysis
Study	N	Tumor	Stage	% stage II	% stage IV	5FU Treatment regimen	MSI test version	MSI test completeness	MSI-H (%)	DFS	OS
Hong 2012 [12]	947	Colorectal	Mixed	40%	16.9%	NR	MSI	Complete	9%	X²	X²
Hutchins 2011 [11]	1913	Colorectal	Mixed	89%	0%	Single	IHC	Partial	11%	X¹	X¹
Jover 2009 [21]	496	Colorectal	Mixed	59%³	0%	Single	MSI+IHC	Complete	12%	X²	X²
Kim 2007 [25]	542	Colon	Mixed	NR	0%	Single	MSI	Complete	18%	X¹	X¹
Sargent 2010 [22]	1027	Colon	Mixed	52%	0%	Single	MSI+IHC	Partial	16%	X²	X²
Storojeva 2005 [23]	160	Colorectal	Mixed	NR	NR	Single	MSI	Complete	13%	X²	X²
Barratt 2002 [26]	368	Colon	Mixed	61%³	NR	Single	MSI	Partial	24%		X
Benatti 2005 [28]	1263	Colorectal	Mixed	58%³	14.6%	Single	MSI	Complete	20%		X
Carethers 2004 [29]	204	Colorectal	Mixed	52%	0%	Single	MSI	Complete	18%		X¹
Elsaleh 2001 [27]	732	Colorectal	Mixed	0%	0%	Single	MSI	Partial	9%		X
Lanza 2006 [30]	325	Colorectal	Mixed	0%	0%	Single	IHC	Partial	13%		X¹
Liang 2002 [33]	244	Colorectal	Advanced	0%	100%	Single	MSI	Complete	21%		X¹
Ohrling 2010 [31]	718	Colorectal	Mixed	50%	0%	Single	IHC	Partial	20%		X¹
Wangefjord 2013 [32]	112	Colorectal	Mixed	0%	0%	Single	IHC	Partial	15%		X¹
Colombino 2002 [35]	91	Rectal	Mixed	42%	NR	Single	MSI	Complete	19%
Dietmaier 2006 [34]	170	Colon	Mixed	0%	0%	Single	MSI	Complete	14%
Ribic	570	Colon	Mixed	55%	0%	Single	MSI	Partial	17%
Total	9312								15%

(5FU = 5 fluorouracil; DFS = disease free survival; OS = overall survival; HR = hazard ratio; NR = not reported; MSI = microsatellite instability; IHC = immunohistochemistry; X = study was included in the analysis).
¹Hazard ratio had to be estimated from study (see Methods).
²Multivariate hazard ratio used in analysis.
³Percentage stage II estimated from data reported on full population prior to exclusions for the final analysis data set.

ISSN: 1471-2407