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Table 1 Outcome measures

From: The effect of individualized NUTritional counseling on muscle mass and treatment outcome in patients with metastatic COLOrectal cancer undergoing chemotherapy: a randomized controlled trial protocol

Measurement Instrument Time point*
Primary outcome
Skeletal muscle area CT (skeletal muscle area L3) T0, T1
Secondary outcomes
Skeletal muscle area CT (skeletal muscle area L3) T0, T2
Quality of life EORTC QLQ C30 (global health- and physical functioning domain) T0, T1, T2
Hand grip strength Hydraulic hand dynamometer T0, T1, T2
Treatment toxicity Common Toxicity Criteria version 4.0 ESP
Treatment intensity Dose index and time index of chemotherapy ESP
Adverse events Medical record ESP
Treatment response Response Evaluation Criteria In Solid Tumors (RECIST) T1, T2
Progression free and overall survival Medical record or general practitioner office After 2 years
  1. *T0: prior to chemotherapy; T1: after three cycles of CAPOX(−B) or four cycles of FOLFOX(−B); T2: after six cycles of CAPOX(−B) or eight cycles of FOLFOX(−B); ESP: entire study period.
  2. CT: Computed Tomography; EORTC QLQ: The European Organisation for Research and Treatment of Cancer: Quality of life questionnaire. L3: third lumbar vertebra.
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BMC Cancer

ISSN: 1471-2407

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