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Table 1 Tumor area as measured by number of pixels (x10 7 ) for A431 xenografts, and ectopic or orthotopic MCF-7 xenografts taken on Day 0 (untreated), 2, 4, 8, or 12 following a single dose of paclitaxel (25 mg/kg, i.p.), doxorubicin (DOX 8 mg/kg, i.v.), or 5-FU (100 mg/kg, i.p.)

From: The effect of chemotherapeutic agents on tumor vasculature in subcutaneous and orthotopic human tumor xenografts

Day A431 MCF-7 Paclitaxel MCF-7 DOX MCF-7 5-FU
Paclitaxel DOX 5-FU SC Ortho SC Ortho SC Ortho
0 1.18 (0.27) 2.29 (0.25) 2.29 (0.25) 4.79 (0.65) 7.40 (4.60) 4.79 (0.65) 7.40 (4.60) 4.79 (0.65) 7.40 (4.60)
2 ______ 2.43 (0.38) 1.96 (0.19) ______ 3.25 (1.41) 6.99 (0.91) 2.53 (0.55) 7.27 (1.16) 5.34 (1.24)
4 1.67 (0.16) 2.70 (0.49) 2.71 (0.49) 3.94 (0.61) 5.04 (1.41) 4.86 (1.33) 3.29 (---) 1.27 (0.53)* 4.49 (2.08)
8 0.99 (0.15) 2.42 (0.36) 1.92 (0.32) 3.78 (0.47) 5.20 (0.80) 3.39 (0.63) 4.06 (1.35) 5.11 (1.17) 5.85 (0.76)
12 0.47 (0.06)* 2.11 (0.47) 1.27 (0.37) 4.57 (0.33) 2.05 (0.82) 3.17 (0.65) ______ 3.34 (0.85) 7.48 (0.83)
  1. Symbols (*) represent statistically significant differences in tumor area compared to control tumors (P < 0.05).