Skip to main content
Figure 4 | BMC Cancer

Figure 4

From: The effect of chemotherapeutic agents on tumor vasculature in subcutaneous and orthotopic human tumor xenografts

Figure 4

Effect of doxorubicin on tumor vasculature in MCF-7 xenografts. The number of total (CD31+) and functional (DiOC7+) blood vessels per tumor area (left panels), and the percentage of functional blood vessels (right panels) present on Day 0, 2, 4, 8, and 12 in MCF-7 A) subcutaneous xenografts or B) orthotopic xenografts following a single dose of doxorubicin (8 mg/kg, administered intravenously). C) The number of total (CD31+) and functional (DiOC7+) blood vessels (per tumor area), and the percentage of functional blood vessels present in Day 12 MCF-7 subcutaneous or orthotopic xenografts. Bars represent the mean of 2-6 tumors; error bars represent standard error of the mean (SEM). Symbols represent statistical significance for percent functional blood vessels (+) as compared to control (Day 0) tumors, and significance between subcutaneous and orthotopic tumors (‚óŹ).

Back to article page