Figure 2

The number of total (CD31+) and functional (DiOC7+) blood vessels (per tumor area), and the percentage of functional blood vessels present in untreated MCF-7 subcutaneous or orthotopic xenografts. Bars represent the mean of 2-12 tumors; error bars represent standard error of the mean (SEM). Scale – numeric values represent number of blood vessels per unit area (x10⁶) for the left and middle panels, and percent functional blood vessels for the right panel. Symbols represent statistical significance between subcutaneous and orthotopic tumors for functional (*) and percent functional (♦) blood vessels.