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Table 5 Risk of recurrence and progression according to the number of urine markers positive in 2-, 3-, and 4-marker combinations

From: Prognostic relevance of positive urine markers in patients with negative cystoscopy during surveillance of bladder cancer

  Markers Number of positive tests n patients Tumor recurrence (12 months) in % p-value (0 vs. 1 vs. 2) Tumor progression (12 months) in % p-value (0 vs. 1 vs. 2) Tumor recurrence (24 months) in % p-value (0 vs. 1 vs. 2) Tumor progression (24 months)in % p-value (0 vs. 1 vs. 2)
2-test-combinations Cytology & FISH 0 62 9.7 .01 1.6 .004 22.6 .001 3.3 <.001
1 23 17.4 0 30.4 8.7
2 29 31.0 17.2 58.6 28.6
Cytology & uCyt+ 0 53 9.4 .002 1.8 .003 20.8 <.001 3.8 <.001
1 36 11.1 0 27.8 5.6
2 25 40.0 20.0 68.0 32.0
Cytology & NMP22 0 37 2.7 .004 0 .002 13.5 <.001 5.4 .004
1 49 16.3 2.0 30.6 4.1
2 28 35.7 17.9 64.3 28.6
FISH & uCyt+ 0 50 12.0 .02 2.0 .004 24.0 <.001 6.0 <.001
1 39 10.3 0 23.1 0
2 25 36.0 20.0 68.0 36.0
FISH & NMP22 0 36 2.8 .008 0 .003 11.1 <.001 2.8 <.001
1 48 20.8 2.1 37.5 8.3
2 30 26.7 16.7 53.3 23.3
uCyt + & NMP22 0 32 0 .001 0 .004 9.4 <.001 3.1 <.001
1 51 19.6 1.9 33.3 7.8
2 31 29.0 16.1 58.1 22.6
3-test-combinations Cytology & FISH & uCYt 0 44 11.4 <.001 2.3 .001 22.7 <.001 4.6 <.001
1 33 6.1 0 21.2 3.0
2 16 25.0 0 37.5 6.25
3 21 38.1 23.8 71.4 38.1
Cytology & FISH & NMP22 0 33 0 .001 0 .001 9.1 <.001 3.0 <.001
1 36 22.2 2.8 38.9 5.6
2 24 12.5 0 25.0 8.3
3 21 38.1 23.8 71.4 33.3
Cytology & uCyt + & NMP22 0 37 2.7 <.001 0 .002 13.5 <.001 5.4 <.001
1 38 15.8 2.6 31.6 2.6
2 11 18.2 0 27.3 9.1
3 28 35.7 17.8 64.3 28.6
FISH & uCyt + & NMP22 0 27 0 .002 0 .001 11.1 <.001 3.7 <.001
1 37 18.9 2.7 27.0 5.4
2 32 15.6 0 37.5 6.25
3 18 38.9 27.8 72.2 38.9
4-test-combination Cytology & FISH & uCyt + & NMP22 0 26 0 <.001 0 <.001 11.5 <.001 3.9 <.001
1 28 17.9 3.6 25.0 3.6
2 30 13.3 0 33.3 6.7
3 14 21.4 0 35.7 7.2
4 16 43.8 31.3 81.3 43.8
  1. p-values are given for Cochrane Armitage tests for trend. FISH = Fluorescence in situ hybridization, NMP22 = Nuclear matrix protein 22, uCyt + = Immunocytology.