Markers | Number of positive tests | n patients | Tumor recurrence (12 months) in % | p-value (0 vs. 1 vs. 2) | Tumor progression (12 months) in % | p-value (0 vs. 1 vs. 2) | Tumor recurrence (24 months) in % | p-value (0 vs. 1 vs. 2) | Tumor progression (24 months)in % | p-value (0 vs. 1 vs. 2) | |
---|---|---|---|---|---|---|---|---|---|---|---|
2-test-combinations | Cytology & FISH | 0 | 62 | 9.7 | .01 | 1.6 | .004 | 22.6 | .001 | 3.3 | <.001 |
1 | 23 | 17.4 | 0 | 30.4 | 8.7 | ||||||
2 | 29 | 31.0 | 17.2 | 58.6 | 28.6 | ||||||
Cytology & uCyt+ | 0 | 53 | 9.4 | .002 | 1.8 | .003 | 20.8 | <.001 | 3.8 | <.001 | |
1 | 36 | 11.1 | 0 | 27.8 | 5.6 | ||||||
2 | 25 | 40.0 | 20.0 | 68.0 | 32.0 | ||||||
Cytology & NMP22 | 0 | 37 | 2.7 | .004 | 0 | .002 | 13.5 | <.001 | 5.4 | .004 | |
1 | 49 | 16.3 | 2.0 | 30.6 | 4.1 | ||||||
2 | 28 | 35.7 | 17.9 | 64.3 | 28.6 | ||||||
FISH & uCyt+ | 0 | 50 | 12.0 | .02 | 2.0 | .004 | 24.0 | <.001 | 6.0 | <.001 | |
1 | 39 | 10.3 | 0 | 23.1 | 0 | ||||||
2 | 25 | 36.0 | 20.0 | 68.0 | 36.0 | ||||||
FISH & NMP22 | 0 | 36 | 2.8 | .008 | 0 | .003 | 11.1 | <.001 | 2.8 | <.001 | |
1 | 48 | 20.8 | 2.1 | 37.5 | 8.3 | ||||||
2 | 30 | 26.7 | 16.7 | 53.3 | 23.3 | ||||||
uCyt + & NMP22 | 0 | 32 | 0 | .001 | 0 | .004 | 9.4 | <.001 | 3.1 | <.001 | |
1 | 51 | 19.6 | 1.9 | 33.3 | 7.8 | ||||||
2 | 31 | 29.0 | 16.1 | 58.1 | 22.6 | ||||||
3-test-combinations | Cytology & FISH & uCYt | 0 | 44 | 11.4 | <.001 | 2.3 | .001 | 22.7 | <.001 | 4.6 | <.001 |
1 | 33 | 6.1 | 0 | 21.2 | 3.0 | ||||||
2 | 16 | 25.0 | 0 | 37.5 | 6.25 | ||||||
3 | 21 | 38.1 | 23.8 | 71.4 | 38.1 | ||||||
Cytology & FISH & NMP22 | 0 | 33 | 0 | .001 | 0 | .001 | 9.1 | <.001 | 3.0 | <.001 | |
1 | 36 | 22.2 | 2.8 | 38.9 | 5.6 | ||||||
2 | 24 | 12.5 | 0 | 25.0 | 8.3 | ||||||
3 | 21 | 38.1 | 23.8 | 71.4 | 33.3 | ||||||
Cytology & uCyt + & NMP22 | 0 | 37 | 2.7 | <.001 | 0 | .002 | 13.5 | <.001 | 5.4 | <.001 | |
1 | 38 | 15.8 | 2.6 | 31.6 | 2.6 | ||||||
2 | 11 | 18.2 | 0 | 27.3 | 9.1 | ||||||
3 | 28 | 35.7 | 17.8 | 64.3 | 28.6 | ||||||
FISH & uCyt + & NMP22 | 0 | 27 | 0 | .002 | 0 | .001 | 11.1 | <.001 | 3.7 | <.001 | |
1 | 37 | 18.9 | 2.7 | 27.0 | 5.4 | ||||||
2 | 32 | 15.6 | 0 | 37.5 | 6.25 | ||||||
3 | 18 | 38.9 | 27.8 | 72.2 | 38.9 | ||||||
4-test-combination | Cytology & FISH & uCyt + & NMP22 | 0 | 26 | 0 | <.001 | 0 | <.001 | 11.5 | <.001 | 3.9 | <.001 |
1 | 28 | 17.9 | 3.6 | 25.0 | 3.6 | ||||||
2 | 30 | 13.3 | 0 | 33.3 | 6.7 | ||||||
3 | 14 | 21.4 | 0 | 35.7 | 7.2 | ||||||
4 | 16 | 43.8 | 31.3 | 81.3 | 43.8 |