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Table 5 Risk of recurrence and progression according to the number of urine markers positive in 2-, 3-, and 4-marker combinations

From: Prognostic relevance of positive urine markers in patients with negative cystoscopy during surveillance of bladder cancer

 

Markers

Number of positive tests

n patients

Tumor recurrence (12 months) in %

p-value (0 vs. 1 vs. 2)

Tumor progression (12 months) in %

p-value (0 vs. 1 vs. 2)

Tumor recurrence (24 months) in %

p-value (0 vs. 1 vs. 2)

Tumor progression (24 months)in %

p-value (0 vs. 1 vs. 2)

2-test-combinations

Cytology & FISH

0

62

9.7

.01

1.6

.004

22.6

.001

3.3

<.001

1

23

17.4

0

30.4

8.7

2

29

31.0

17.2

58.6

28.6

Cytology & uCyt+

0

53

9.4

.002

1.8

.003

20.8

<.001

3.8

<.001

1

36

11.1

0

27.8

5.6

2

25

40.0

20.0

68.0

32.0

Cytology & NMP22

0

37

2.7

.004

0

.002

13.5

<.001

5.4

.004

1

49

16.3

2.0

30.6

4.1

2

28

35.7

17.9

64.3

28.6

FISH & uCyt+

0

50

12.0

.02

2.0

.004

24.0

<.001

6.0

<.001

1

39

10.3

0

23.1

0

2

25

36.0

20.0

68.0

36.0

FISH & NMP22

0

36

2.8

.008

0

.003

11.1

<.001

2.8

<.001

1

48

20.8

2.1

37.5

8.3

2

30

26.7

16.7

53.3

23.3

uCyt + & NMP22

0

32

0

.001

0

.004

9.4

<.001

3.1

<.001

1

51

19.6

1.9

33.3

7.8

2

31

29.0

16.1

58.1

22.6

3-test-combinations

Cytology & FISH & uCYt

0

44

11.4

<.001

2.3

.001

22.7

<.001

4.6

<.001

1

33

6.1

0

21.2

3.0

2

16

25.0

0

37.5

6.25

3

21

38.1

23.8

71.4

38.1

Cytology & FISH & NMP22

0

33

0

.001

0

.001

9.1

<.001

3.0

<.001

1

36

22.2

2.8

38.9

5.6

2

24

12.5

0

25.0

8.3

3

21

38.1

23.8

71.4

33.3

Cytology & uCyt + & NMP22

0

37

2.7

<.001

0

.002

13.5

<.001

5.4

<.001

1

38

15.8

2.6

31.6

2.6

2

11

18.2

0

27.3

9.1

3

28

35.7

17.8

64.3

28.6

FISH & uCyt + & NMP22

0

27

0

.002

0

.001

11.1

<.001

3.7

<.001

1

37

18.9

2.7

27.0

5.4

2

32

15.6

0

37.5

6.25

3

18

38.9

27.8

72.2

38.9

4-test-combination

Cytology & FISH & uCyt + & NMP22

0

26

0

<.001

0

<.001

11.5

<.001

3.9

<.001

1

28

17.9

3.6

25.0

3.6

2

30

13.3

0

33.3

6.7

3

14

21.4

0

35.7

7.2

4

16

43.8

31.3

81.3

43.8

  1. p-values are given for Cochrane Armitage tests for trend. FISH = Fluorescence in situ hybridization, NMP22 = Nuclear matrix protein 22, uCyt + = Immunocytology.