Prognostic relevance of positive urine markers in patients with negative cystoscopy during surveillance of bladder cancer

Table 3 Prediction of progression by single urine markers in case of negative cystoscopy in the follow up of non muscle invasive bladder cancer

Test	Result	n	Rate of tumor progression in % (12 months)	Hazard ratio	p-value	Rate of tumor progression in % (24 months)	Hazard ratio	p-value
Cytology	-	75	1.3	11.6 (1.7-226.1)	.008	4.0	7.2 (2.0-34.2)	<.001
Cytology	+	39	13.5	11.6 (1.7-226.1)	.008	23.1	7.2 (2.0-34.2)	<.001
FISH	-	72	1.4	9.72 (1.5-189.9)	.01	4.2	6.2 (1.7-29.7)	.004
FISH	+	42	12.2	9.72 (1.5-189.9)	.01	21.4	6.2 (1.7-29.7)	.004
uCyt+	-	67	1.5	8.3 (1.3-161.0)	.025	4.5	5.1 (1.4-23.8)	.01
uCyt+	+	66	11.1	8.3 (1.3-161.0)	.025	19.2	5.1 (1.4-23.8)	.01
NMP22	-	48	0	28×10⁶ (2.04-n.a.)	.009	6.2	2.4 (0.7-11.1)	.19
NMP22	+	66	9.2	28×10⁶ (2.04-n.a.)	.009	13.6	2.4 (0.7-11.1)	.19

FISH = Fluorescence in situ hybridization, uCyt + = Immunocytology, NMP22 = Nuclear matrix protein 22.

ISSN: 1471-2407