Prognostic relevance of positive urine markers in patients with negative cystoscopy during surveillance of bladder cancer

Table 2 Prediction of recurrence by single urine markers in case of negative cystoscopy in the follow up of non muscle invasive bladder cancer

Urine marker	Result	n	Rate of tumor recurrence in % (after 12 months)	Hazard ratio	p-value	Rate of tumor recurrence in % (after 24 months)	Hazard ratio	p-value
Cytology	-	75	9.3	4.3 (1.6-12.7)	.004	21.9	3.9 (1.75-9.2)	<.001
Cytology	+	39	30.7	4.3 (1.6-12.7)	.004	52.6	3.9 (1.75-9.2)	<.001
FISH	-	72	12.5	2.2 (0.8-6.0)	.12	25.0	3.3 (1.5-7.6)	.01
FISH	+	42	23.8	2.2 (0.8-6.0)	.12	47.6	3.3 (1.5-7.6)	.01
uCyt+	-	67	10.5	2.93 (1.2-8.0).	.03	22.4	2.7 (1.2-6.2)	.003
uCyt+	+	66	25.5	2.93 (1.2-8.0).	.03	43.8	2.7 (1.2-6.2)	.003
NMP22	-	48	6.3	4.79 (1.47-21.6)	.007	16.7	4.2 (1.7-10.8)	.001
NMP22	+	66	24.4	4.79 (1.47-21.6)	.007	43.8	4.2 (1.7-10.8)	.001

FISH = Fluorescence in situ hybridization, uCyt + = Immunocytology, NMP22 = Nuclear matrix protein 22.

ISSN: 1471-2407