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Figure 1 | BMC Cancer

Figure 1

From: HNRNP G and HTRA2-BETA1 regulate estrogen receptor alpha expression with potential impact on endometrial cancer

Figure 1

Sequence analyses ofERaexon7 and potential mode of action of HNRNPG and HTRA2-BETA1 onERaexon7 splicing regulation. (A) Sequence analyses of ERa exon7. SS*: splice site; RS: arginine/serine rich domain of HTRA2-BETA1 (domain is required for protein-protein interaction and recruiting of other splicing factors to exons). ERa exon7 sequence is shown between 5’SS and 3’SS. Its poly-pyrimidine tract sequence is shown upstream of 5’SS and its 3’ intron sequence is shown downstream of 3’SS. Binding motifs of each splicing factor are stated out below exon7 sequence and are indicated in original sequence, respectively. (B) The antagonizing effect of HTRA2-BETA1 to HNRNP I is shown, the mechanism of this function is not clear. (C) The antagonizing effect of HNRNP G on HTRA2-BETA1 is shown. We propose that these two factors antagonize each other in RNA binding in a concentration dependent manner.

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