Figure 4
From: Hunk/Mak-v is a negative regulator of intestinal cell proliferation
Survival and tumour burden analysis. A Kaplan-Meier survival curve of aged cohorts of ApcMinHunk+/+ (n = 23), ApcMinHunk+/− (n = 27) and ApcMinHunk−/− (n = 23) mice, demonstrating that no significant differences in survival between the cohorts. B Box plot displaying the total number of tumours found at death in the aged cohorts of ApcMinHunk+/+ and ApcMinHunk−/− mice. The box encompasses the first quartile (at bottom) to the third quartile (at top) of the data set and the horizontal boxed line represents the median. ** p < 0.01 Mann–Whitney U test. C Box plot displaying the size of tumours found at death in the aged cohorts of ApcMinHunk+/+ and ApcMinHunk−/− mice. D qRT-PCR analysis showing relative expression levels of Axin2 and Wif1 in normal colonic tissue (colon) and adjacent adenoma tissue (polyp) taken from 4 aged matched animals from the different genotypes. * p < 0.05 Mann–Whitney U test between ΔCT values.