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Figure 3 | BMC Cancer

Figure 3

From: Hunk/Mak-v is a negative regulator of intestinal cell proliferation

Figure 3

Characterisation of the intestine following Hunk-kinase loss. A Representative images showing no difference in Alcain Blue staining (Goblet cells) and Lysozyme IHC (Paneth cells) in the different genotypes, and an increase in BRDU incorporation 2 hours post administration. B Haematoxylin and eosin stained intestinal sections were used to score the percentage of Mitotic and Apoptotic bodies within intestinal crypts, while BrdU IHC stained sections were used to score BrdU incorporation 2 hours post administration. Bar charts show means ± SD determined by scoring at least 50 half crypts within 4 individuals from each cohort. * denotes p < 0.05 Mann–Whitney U test. C Accumulative frequency of BrdU positive cell position along the crypt-villus axis, 2 hours and 24 hours post administration. Significant differences between the genotypes were detected at both time points using Kolmogorov–Smirnov test, a test designed to examine probability distribution patterns.

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