Effect of SMC1A silencing on the tumorigenesis of CRC in vivo. (A) The subcutaneous xenograft murine model. (B) Representative images of tumors formed in the mice in which Lv-shSMC1A- or Lv-shCon-infected RKO cells were implanted. (C) Changes in the tumor volume on the 6th, 9th, 12th, 15th and 21st days after the cells were implanted subcutaneously. (D) Changes in the tumor weight in mice after SMC1A silencing. (E) Expression analysis of SMC1A in tumor tissues collected from mice. ***p < 0.01 in comparison with non-silencing shRNA infected control.