Table 1 Summary of clinical data including age, sex and tumor size (Tu size) as well as relevant diagnostic immunohistochemistry markers for lung NET, including proliferation index (Mib-1), neuroendocrine (Synapto, Chrom A) and lung differentiation (TTF1)

TC

58

53

23/35

2.2

1.6

98%

98%

45%

AC

42

49

14/28

2.8

3.1

100%

98%

48%

LCNEC

32

64

22/10

3.5

57

91%

63%

94%

SCLC

60

62

41/19

3.3

51

93%

50%

80%

All 4 histotypes

p

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

tau

0.208

−0.245

0.222

0.564

−0.416

−0.634

0.379

Low vs. high grade

p

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

<0.001

tau

0.291

−0.315

0.215

0.647

−0.527

−0.723

0.467

LCNEC vs. SCLC

p

n.s.

n.s.

n.s.

n.s.

n.s.

n.s.

n.s.

tau