Figure 1

Representative H-scores in nucleus (nucl) and cytosol (cyto) for PTEN immunoreactivity using Mab clone 6H2.1. Original magnifications are 200-400x, except insert F (12.5x). A. Normal lung alveolar pneumocytes type. B. TC with PTEN score nucl 0 and cyto 0. C. LCNEC with nucl 0 and cyto 3x100. Necrotic cells on the left side were not counted. D. TC with nucl 3x100 and cyto 1x100. E. SCLC with nucl 0 and cyto 3x100. F. TC with nucl 3x100 and cyto 3x100. Insert: Whole section of lung TC showing homogenous PTEN staining across the tumor surface. Holes represent areas of removed tissue punches.