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Table 1 Patient characteristics

From: Local control in metastatic neuroblastoma in children over 1 year of age

   

N

%

Age

Median (months)

36

  

Range (months)

13-216

 

Gender

Male

 

35

60

 

Female

 

23

40

Site of Metastasis

Bone/Bone Marrow/Lymph node

 

48

83

 

Lymph node alone

 

3

5

 

Others

 

7

12

Primary Sites

Retroperitoneal

 

12

21

 

Adrenal Gland

 

41

71

 

Thorax

 

5

8

MYCN

Amplified

 

19

34

(available for 56 pt)

Non amplified or MYCN gain

 

37

66

Induction CT

ICE/CECAT

 

21

36

 

Topo NB

 

37

64

Primary Tumor Reduction before Surgery*

<50%

 

4

8

 

>50%, <95%

 

34

68

 

>95%

 

12

24

Surgery

Radical

 

45

78

 

Not Radical

 

13

22

Response before HDC**

CR/VGPR

 

21

37

 

PD

 

11

20

 

PR

 

24

43

RT

Yes

 

28

48

 

No

 

30

52

  1. LEGEND: pt, patient; BX, biopsy; CR, complete remission; VGPR, very good partial remission; PD, progressive disease; PR, partial response. For “others” site of metastasis was considered Bone or/and Bone Marrow or/and Lymph node plus lung or/and liver metastatis.
  2. *In 7 patients surgery was performed at diagnosis, one patient died for an acute bleeding after accidental removal of central vein catheter.
  3. **Two patients were not considered for this analysis; one patient died for acute bleeding and the later one died for acute renal failure.