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Table 1 Prior studies of circadian variability in 5-fluorouracil plasma levels during CVI

From: Circadian variation in plasma 5-fluorouracil concentrations during a 24 hour constant-rate infusion

Reference Pts 5-FU dose (mg/m2/d) Sampling (hours) Data analysis Peak time Trough time Estimated [5-FU] change (peak to trough)
Petit [6] 7 450-966 Q3 ANOVA of mean transformed [5-FU] by time (% change from pt mean) 1:00 13:00 −43% (2× amplitude from cosinor analysis)
Harris [4] 7 300 Q3 Cosinor analysis of transformed [5-FU] (% change from pt mean) 11:00 23:00 −80% (mean of individual patient peaks and troughs)
Sparano [7] 15 150-300 Q1-16 Cosinor analysis of transformed [5-FU] (% change from pt mean) 8:00 20:00 −2.5 standard deviations from individual’s mean [5-FU] (at individual’s peak and trough)
Metzger [8] 4 600 Q6 ANOVA of mean [5-FU] by time 4:00 13:00 −88% (mean [5-FU] at the population’s peak and trough)
Van Kuilenburg [9] 5 300-450 Q4 Not stated No circadian variation observed
Strocchi [10] 9 600 Q3 Not stated 3 of 9 pts had “marked circadian variation” but peak was variable
Takimoto [11] 14 1758 Q3 ANOVA of mean [5-FU] by time (Kruskal-Wallis test) No consistent circadian variation observed; 5 Fu concentrations within individuals varied 1.7 fold
Kuwahara [12] 35 400-550 Q12 Comparison of two timepoints Higher concentrations observed at 17:00 and lower at 5:00. Difference observed only at lower dosage.