Significant correlation between urinary N1, N12-diacetylspermine and tumor invasiveness in patients with clinical stage IA non-small cell lung cancer

Table 3 Relationship between pathologic invasive factors and clinicopathological factors

Factors	Invasive tumor	Non-invasive tumor	p-value*
Age (years)
≤69	19	68
>69	30	54	0.062
Gender
male	30	54
female	19	68	0.062
Smoking history
Never-smoker	11	47
Smoker	38	75	0.051
Tumor size (cm)
≤2.0	20	84
>2.0	29	38	0.001
Serum CEA level (mg/dL)
≤5.0	35	113
>5.0	14	9	<0.001
Histological type
adenocarcinoma	35	102
non-adenocarcinoma	14	20	0.090
Urine DiAcSpm level (nmol/g creatinine)
low	15	70
high	34	520	0.002
TDR
≥0.75	4	45
<0.75	45	77	<0.001

*Fisher’s exact test, DiAcSpm = diacetylspermine, CEA = carcinoembryonic antigen level, TDR = tumor disappearance rate.