Table 3 Univariate and multivariate analysis of clinical features associated with overall survival

3-miRNA signature (high-risk vs. low-risk)

2.49 (1.300-4.750)

0.006

Gender (M vs. F)

1.49 (0.699-3.153)

0.303

Age (≥50 vs. <50)

1.30 (0.665-2.557)

0.439

ALT (>40 vs. ≤40)

0.69 (0.302-1.572)

0.375

AST (>45 vs. ≤45)

0.63 (0.220-1.781)

0.38

TBIL (>20.5 vs. ≤20.5)

0.57 (0.222-1.469)

0.245

HBsAg (Positive vs. Negative)

0.90 (0.475-1.714)

0.755

AFP (≤25 vs. >25)

3.43 (1.014-11.574)

0.047

CA19-9 (>35 vs. ≤35)

1.91 (0.977-3.746)

0.058

CEA (>5 vs. ≤5)

1.81 (0.909-3.611)

0.091

Cirrhosis (Yes vs. No)

1.32 (0.669-2.613)

0.442

Edmondson Steiner grade (I + II vs. III)

1.02 (0.533-1.953)

0.951

T stage (T2b + T3 vs. T1 + T2a)

2.48 (1.282-4.780)

0.007

N stage (N1 vs. N0)

3.07 (1.587-5.920)

0.001

TNM stage (III + IV vs. I + II)

3.72 (1.933-7.177)

<0.001

3-miRNA signature (high-risk vs. low-risk)

2.13 (1.108-4.107)

0.023

TNM stage (III + IV vs. I + II)

3.37 (1.733-6.651)

<0.001