Figure 4

Growth stimulation by HGF and FGFs and growth inhibition by MET inhibitor and FGFR inhibitor. HGF stimulates the proliferation of two cell lines (KYSE170 and KYSE220) by more than 1.36 fold, while the addition of FGFs (1, 7, and 10) induces a 1.25-fold or higher growth stimulation in 11 cell lines. MET inhibitor (PHA-665752) inhibits proliferation by 25% or more in six cell lines. FGFR inhibitor (PD-173074) inhibits proliferation by 25% or more in six cell lines, three of which are also growth inhibited by MET inhibitor.