Effects of targeting cMET on pancreatic cancer cells. A) cMET expression was detectable in HPAF-II, L3.6pl, BxPC3 but not in parental MiaPaCa2 pancreatic cancer cell lines. B) Incubation of HPAF-II cells with the cMET inhibitor INC280 has no effect on constitutive growth. When cells were stimulated with HGF, a significant growth increase was observed (#P < 0.05). This was abrogated by cMET inhibition with INC280 (*P < 0.05). C) HGF induces cancer cell motility (#P < 0.05) that can be efficiently blocked by INC280 (*P < 0.05). Constitutive motility remains unaffected. D) Treatment with INC280 disrupts HGF-mediated phosphorylation of Akt, ERK and FAK after 4 and 24 hours of treatment. Results in 1B-1D are shown for HPAF-II; similar results were obtained from L3.6pl and Panc02. Bars = SEM.