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Table 2 Univariate and multivariate analyses of disease-free survival

From: Number of negative lymph nodes is associated with disease-free survival in patients with breast cancer

Characteristic

Univariate

Multivariate

 

HR

95% CI

Pvalue

HR

95% CI

Pvalue

Age

      

 <35

1

  

1

  

 ≥35

0.618

0.476-0.803

<0.001*

0.679

0.522-0.883

0.004*

Menopause

      

 Premenopause

1

  

  

 Postmenopause

0.995

0.822-1.205

0.960

  

pT stage

      

 T1

1

  

1

  

 T2

1.699

1.361-2.120

<0.001*

1.361

1.088-1.704

0.007*

 T3

2.844

2.036-3.972

<0.001*

1.585

1.116-2.252

0.010*

 T4

3.150

1.933-5.134

<0.001*

1.798

1.091-2.963

0.021*

pN stage

      

 N0

1

  

1

  

 N1

2.187

1.746-2.740

<0.001*

2.083

1.658-2.616

<0.001*

 N2

3.139

2.322-4.244

<0.001*

2.506

1.817-3.456

<0.001*

 N3

6.725

5.236-8.638

<0.001*

4.575

3.315-6.313

<0.001*

ER

      

 Negative

1

  

1

  

 Positive

0.586

0.504-0.682

<0.001*

0.720

0.582-0.892

0.003*

PR

      

 Negative

1

  

1

  

 Positive

0.620

0.533-0.722

<0.001*

0.790

0.636-0.980

0.032*

Her2

      

 Negative

1

  

  

 Positive

0.977

0.871-1.096

0.693

  

Number of NLNs (continuous variable)

0.913

0.896-0.930

<0.001*

0.977

0.958-0.997

0.022*

  1. DFS, disease-free survival; HR, hazard ratio; CI, confidence interval; ER estrogen receptor; PR, progesterone receptor; Her-2, human epidermal growth factor receptor-2; NLNs, negative lymph nodes.
  2. *P < 0.05 indicates a significant difference.