From: Clinical outcome of patients with pancreatic metastases from renal cell cancer
Variables | Pancreatic metastasis | Non-pancreatic metastasis | P | |||
---|---|---|---|---|---|---|
Male/female | n (%) | 12/8 | (60%/40%) | 184/58 | (76%/24%) | 0.11 |
Age at Dx of RCC* | 59.7 | (52.5–62.5) | 61.7 | (54.6-69.3) | 0.16 | |
Age at Dx of metastasis | 66.2 | (62.3–69.9) | 63.6 | (56.4-70.2) | 0.09 | |
Metastatic sites | n (%) | |||||
Pancreas | 20 | (100%) | 0 | (0%) | ||
Lung | 4 | (20%) | 194 | (80%) | <0.0001 | |
Bone | 0 | (0%) | 63 | (26%) | 0.009 | |
Kidney | 5 | (25%) | 2 | (1%) | <0.0001 | |
Lymph nodes | 3 | (15%) | 77 | (32%) | 0.117 | |
Liver | 3 | (15%) | 19 | (8%) | 0.268 | |
Adrenal gland | 2 | (10%) | 39 | (16%) | 0.469 | |
Synchronous: metachronous (n) | 3 /17 | (15%/85%) | 153/89 | (63%/37%) | <0.0001 | |
Period from Dx of RCC to metastasis (years)* | 7.8 | (4.2–12.7) | 0 | (0–0.7) | <0.0001 | |
Metastasectomy (n) | (Yes/No) | 15/5 | (75%/25%) | 56/186 | (23%/77%) | <0.0001 |
Molecular targeted therapy (n) | (Yes/No) | 6/14 | (30%/70%) | 98/144 | (40%/60%) | 0.357 |
Median OS from the Dx of metastasis (years)# | Not reached | 2.7 | (1.8-3.6) | <0.0001 |