Figure 1
From: Impact of diabetes type II and chronic inflammation on pancreatic cancer
Characterisation of the syngeneic orthotopic PDA model. (A) 6606PDA cells were injected on day 0 into the head of the pancreas of non-diabetic (lean) or diabetic (obese) mice. Chronic pancreatitis was induced by ip injection of cerulein in non-diabetic (lean Cer) and diabetic (obese Cer) cohorts of mice three times a day on the indicated days, whereas control non-diabetic (lean Sham) and diabetic (obese Sham) mice received 0.9% saline solution. Tissue samples were analyzed on day 20. (B) The correct injection of carcinoma cells could macroscopically be verified. (C) A representative histology of a PDA reveals necrotic areas (arrowhead), but also vital cells with partially epithelial morphology (arrow). Bar = 50 μm.