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Table 1 Comparison of IHC, FISH and SNP data

From: High-density SNP arrays improve detection of HER2 amplification and polyploidy in breast tumors

  IHC/FISH SNP array
Tumor sample number HER2 IHC HER2 FISH HER2 segment copy number HER2/CEP17 ratio HER2 copy number status
1 0 n/a 1,98 balance normal
2 0 n/a 2,35 HER2+ amp*
3 0 1,92 1,81 balance normal
4 0 n/a 2,06 balance normal
5 0 n/a 2,04 balance normal
6 0 n/a 1,72 cent+ del
7 0 n/a 1,67 balance del
8 0 n/a 1,83 balance normal
9 0 n/a 1,51 cent+ del
10 0 n/a 2,51 balance amp*
11 0 n/a 1,78 balance del
12 0 n/a 1,85 balance normal
13 1 n/a 1,97 balance normal
14 1 n/a 2,08 balance normal
15 1 0,83 2,33 balance amp*
16 1 0,80 1,70 balance del
17 1 0,80 1,80 cent+ normal
18 1 0,86 2,49 balance amp*
19 1 n/a 2,06 balance normal
20 1 n/a 2,09 balance normal
21 1 n/a 1,96 balance normal
22 1 n/a 1,97 balance normal
23 1 n/a 2,13 balance normal
24 1 n/a 1,90 balance normal
25 1 n/a 1,87 balance normal
26 1 n/a 4,46 balance amp*
27 1 n/a 2,34 balance amp*
28 2 1,41 2,45 balance amp*
29 2 1,54 2,16 balance normal
30 2 3,05* 2,04 balance normal
31 2 2,69* 2,48 balance amp*
32 2 2,42* 1,75 cent+ del
33 2 1,73 1,99 balance normal
34 2 2,65* 1,92 balance normal
35 2 1,50 1,91 balance normal
36 2 1,57 2,00 balance normal
37 2 1,68 1,79 balance del
38 2 1,90 1,84 balance normal
39 2 1,60 2,05 balance normal
40 2 1,58 1,89 balance normal
41 2 2,13* 2,73 balance amp*
42 2 1,54 2,04 balance normal
43 2 1,82 1,54 balance del
44 2 1,90 1,77 balance del
45 2 1,66 2,33 balance amp*
46 2 1,48 2,04 balance normal
47 2 1,73 1,98 balance normal
48 2 1,67 2,36 balance amp*
49 2/3 0,93/8,8 11,10 HER2+ amp*
50 2 1,81 2,04 balance normal
51 2 1,58 2,65 HER2+ amp*
52 2 1,60 2,23 balance amp*
53 2 2,27* 8,03 HER2+ amp*
54 2 1,87 2,91 balance amp*
55 2 1,24 2,66 balance amp*
56 2 7,38* 7,01 HER2+ amp*
57 2 1,00 1,88 balance normal
58 2 8,60* 7,98 HER2+ amp*
59 2 3,24* 3,18 HER2+ amp*
60 3*/1 1,65 2,00 balance normal
61 3 4,11* 5,28 HER2+ amp*
62 3 7,00* 4,58 HER2+ amp*
63 3*/2 1,50 2,05 balance normal
64 3* n/a 3,15 HER2+ amp*
65 3* 1,35 3,75 HER2+ amp*
  1. Asterisk indicates HER2 positive results, while bold indicates samples that have been reanalyzed. Abbreviations: amp amplified CEP17 centromere on chromosome 17, del deletion, FISH fluorescent in situ hybridization, HER2 human epidermal growth factor receptor-2, IHC immunohistochemistry, n/a not analysed.